Azolimine

Azolimine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Azolimine,ZYF Pharm Chemical

• Verwenden

  Diuretic.

• Manufacturing Process

  2 methods of producing of 1-phenyl-2-imino-3-methyl-4-oxoimidazolidine:
  1). In 29 ml of water containing 1.0 g of sodium hydroxide was dissolved 3.55 g of phenylcyanamide. To the clear solution was added 2.7 g of Nmethylchloroacetamide. The reaction mixture was left to stir for 120 h at room temperature. The solvent was therefore stripped off on a rotary evaporator under vacuum. The solid residue was slurried in dilute alkali and filtered to yield 1.0 g (21%) of 1-phenyl-2-imino-3-methyl-4-oxoimidazolidine, melting point 163°-165°C.
  2). 133.0 g of phenylcyanamide hemihydrate was dissolved in 1500 ml of absolute alcohol. To this solution was added 55.0 g of sodium methoxide. This mixture was stirred for 30 min and 113.0 g of N-methylchloroacetamide then added. This mixture was heated to reflux for 4 h and allowed to stand overnight. The white precipitate was filtered and washed with ethanol. This ethanol filtrate was concentrated on the rotating evaporator and cooled giving additional product. Both crops of product were combined, washed with water and dried to give 87.0 g (47%) of 1-phenyl-2-imino-3-methyl-4- oxoimidazolidine, melting point 169°-170°C.

• Therapeutic Function

  Diuretic

Azolimine Upstream-Materialien And Downstream Produkte

Azolimine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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