1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl-

1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling. CU-CPD107, a tetrasubstituted imidazole, inhibits R848-induced TLR8 signaling and shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling.[1]

• Einzelnachweise

  [1] Yang Y, et al. Nat Commun. 2021 Jul 16;12(1):4351.

1H-Imidazole-1-ethanol, 2-(ethoxymethyl)-4-iodo-α,α-dimethyl-5-phenyl- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(7)Suppliers