3,3-Diethyl-5-methyl-2,4-piperidindion

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H317：Kann allergische Hautreaktionen verursachen.

  H318：Verursacht schwere Augenschäden.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P272：Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P310：Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen.

  P321：Besondere Behandlung

  P330：Mund ausspülen.

  P332+P313：Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P333+P313：Bei Hautreizung oder -ausschlag: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P362：Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

  P363：Kontaminierte Kleidung vor erneutem Tragen waschen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

methyprylon Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Nearly white, crystalline powder; slightcharacteristic odor; bitter taste. Melting range 74–77C. Soluble in water; very soluble in alcohol, chlo-roform, ether, and benzene.

• Originator

  Noludar,Roche,US,1955

• Verwenden

  Medicine (sedative, hypnotic).

• Definition

  ChEBI: Methyprylon is an organic molecular entity.

• Manufacturing Process

  24 parts by weight of powdered sodium are suspended in 100 parts by volume of absolute benzene and to this suspension is added a freshly prepared solution of 150 parts by weight of methyl formate and 165 parts by weight of 2,4-dioxo-3,3-diethyl-piperidine in 900 parts by volume of absolute benzene. By cooling with cold water, the temperature is maintained at 25° to 28°C. After being stirred for 12 hours 200 parts by volume of 0.6 N sodium hydroxide are added while cooling. The aqueous layer is separated and acidified to Congo red by means of 35% hydrochloric acid. The 2,4-dioxo-3,3- diethyl-5-oxymethylenepiperidine is precipitated in good yield as a solid. After having been recrystallized in chloroform/petroleum ether it melts at 140° to 141°C.
  5 parts by weight of 2,4-dioxo-3,3-diethyl-5-oxymethylene-piperidine are hydrogenated in 25 parts by volume of methanol in the presence of about 2 parts by weight of Raney nickel at 120°C and under an elevated pressure of 100 atm. Once 2 mols of hydrogen are absorbed, the hydrogenation is interrupted, the solution is separated from the catalyst and concentrated and the residue is distilled in vacuo. The distillate, boiling between 178° and 185°C under a pressure of 16 mm, consists of 2,4-dioxo-3,3-diethyl-5-methylpiperidine, which melts at 74° to 75°C.
  The same compound is obtained when proceeding according to the following alternative procedure. A mixture of 39.4 parts by weight of 2,4-dioxo-3,3- diethyl-5-oxymethylenepiperidine and 27 parts by weight of dibutylamine are heated to 150°C in a closed vessel. The 2,4-dioxo-3,3-diethyl-5-dibutylaminomethylene-piperidine formed melts at 77°C after having been recrystallized in petroleum ether.
  31 parts by weight of the latter compound are hydrogenated in 150 parts by volume of alcohol, containing 6 parts by weight of acetic acid, in the presence of 10 parts by weight of Raney nickel, at 120°C and under an elevated pressure of 100 atm. The catalyst is separated and the solution is distilled in vacuo. The 2,4-dioxo-3,3-diethyl-5-methyl-piperidine boils between 178° and 185°C under a pressure of 16 mm and melts at 74° to 75°C.

• Trademarks

  Nolurate.

• Therapeutic Function

  Sedative, Hypnotic

• Weltgesundheitsorganisation (WHO)

  Methyprylon, a piperidine derivative, was introduced in 1955 for use as a sedative-hypnotic drug. Habituation, tolerance, physical dependence and addiction can occur and methyprylon is controlled under Schedule IV of the 1971 Convention on Psychotropic Substances. (Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV), , , 1971)

• Hazard

  Abuse may cause addiction.

methyprylon Upstream-Materialien And Downstream Produkte