6-Methylisochinolin

Bezeichnung:6-Methylisochinolin

CAS-Nr42398-73-2

Englisch Name:6-Methylisoquinoline

CBNumberCB5879955

SummenformelC10H9N

Molgewicht143.19

MOL-Datei42398-73-2.mol

Synonyma

6-Methylisochinolin

6-Methylisochinolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	85.5°C
Siedepunkt	246.29°C (estimate)
Dichte	1.0584 (estimate)
Brechungsindex	1.6103 (estimate)
pka	5.85±0.10(Predicted)
Aggregatzustand	solid
Farbe	Beige
CAS Datenbank	42398-73-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36
S-Sätze:	26-24/25
Hazard Note	Irritant
HS Code	29334900

Gefahreninformationscode (GHS)

6-Methylisoquinoline Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Light beige powder
Verwenden
6-Methylisoquinoline (cas# 42398-73-2) is a useful reagent for the green preparation of polyfluoroarylated heterocyclic compounds.
synthetische
A benzene solution (50 ml, CAUTION) of equimolar amounts of p-tolualdehyde (8.4 g, 0.07 mol) and aminoacetaldehyde dimethyl acetal (7.35 g, 0.07 mol) is refluxed overnight into a Dean and Stark trap. The solution is evaporated in vacuo and then twice evaporated again with added benzene and the viscous oil dissolved in dry tetrahydrofuran. This solution is cooled to - 10 °C and 1 equivalent of ethyl chloroformate (7. 1 ml, 0.07 mol) is added with rapid stirring and the mixture stirred for a further 5 minutes. The cooling bath is removed and 1.2 equivalents of trimethyl phosphite ( 10.5 ml, 0.09 mol) is added with stirring. The solution is stirred at room temperature for 1 5 hours and then evaporated t o an oil. The oil is then re-evaporated twice with added toluene to remove traces of trimethyl phosphite. The oil is dissolved in dry dichloromethane, 6 equivalents of titanium(1v) chloride (50 ml, 0.45 mol) is added and the solution refluxed for 36 hours under a drying tube. The cooled solution is shaken with 1 equivalent of aqueous sodium hydroxide solution to neutrality, whereupon titanium(1v) oxide precipitates as a white solid. The filtered organic layer is extracted with 3 M hydrochloric acid, and the extract is washed with dichloromethane, basified strongly with aqueous alkali, and extracted with dichloromethane. This organic extract is dried over anhydrous sodium sulphate and evaporated to afford 6-methylisoquinoline (yield 7 1 %, m.p. 88 °C).
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 3344, 1983 DOI: 10.1021/jo00167a043

6-Methylisoquinoline Upstream-Materialien And Downstream Produkte

6-Methylisochinolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

42398-73-2, 6-Methylisoquinoline Verwandte Suche:

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