(-)-THALIDOMIDE Struktur

(-)-THALIDOMIDE

Bezeichnung:(-)-THALIDOMIDE

CAS-Nr841-67-8

Englisch Name:(-)-THALIDOMIDE

CBNumberCB5762707

SummenformelC13H10N2O4

Molgewicht258.23

MOL-Datei841-67-8.mol

(-)-THALIDOMIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	269-271°C
Siedepunkt	401.48°C (rough estimate)
Dichte	1.2944 (rough estimate)
Brechungsindex	1.5300 (estimate)
storage temp.	-20°C Freezer
Löslichkeit	DMSO: soluble
pka	10.70±0.40(Predicted)
Aggregatzustand	solid
Farbe	white
Optische Aktivität	[α]23/D 62.6°, c = 2 in DMF(lit.)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	61-22
S-Sätze:	53-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	TI4925050

Gefahreninformationscode (GHS)

(-)-THALIDOMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R61:Kann das Kind im Mutterleib schädigen.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Needles
Verwenden
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.
Verwenden
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative
Definition
ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has S-configuration at the chiral centre.
Allgemeine Beschreibung
Thalidomide is a stereoisomer, which exists in two enantiomeric states. The S enantiomer is teratogenic. Thalidomide consists of two linked rings, a phthalimide and glutarimide ring.
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits the biosynthesis of tumor necrosis factor α (TNF-α), which is essential for inflammatory response. It is an anti-emetic drug and is used to treat morning sickness in pregnant women. Thalidomide is also used to treat leprosy, multiple myeloma, Crohn′s disease and human immunodeficiency virus (HIV) infection. Thalidomide also inhibits angiogenesis. It is associated with several diseases such as, peripheral neuropathy, facial palsies, Duane syndrome and autism.

(-)-THALIDOMIDE Upstream-Materialien And Downstream Produkte

(-)-THALIDOMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

841-67-8, (-)-THALIDOMIDE Verwandte Suche:

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