Daminozid

Bezeichnung:Daminozid

CAS-Nr1596-84-5

Englisch Name:Daminozide

CBNumberCB5752603

SummenformelC6H12N2O3

Molgewicht160.17

MOL-Datei1596-84-5.mol

Synonyma

Daminozid

Daminozid physikalisch-chemischer Eigenschaften

Schmelzpunkt	162-164 °C(lit.)
Siedepunkt	286.06°C (rough estimate)
Dichte	1.2751 (rough estimate)
Brechungsindex	1.4500 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Soluble in DMSO (up to 50 mg/ml), or in Water (up to 20 mg/ml with warming).
pka	5.59±0.10(Predicted)
Aggregatzustand	White powder
Farbe	White crystalline
Wasserlöslichkeit	100 g/L
Merck	14,2810
BRN	1863230
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, wetting agents, oils, copper-containing compounds.
InChIKey	NOQGZXFMHARMLW-UHFFFAOYSA-N
CAS Datenbank	1596-84-5(CAS DataBase Reference)
NIST chemische Informationen	Butanedioic acid, mono(2,2-dimethylhydrazide)(1596-84-5)
EPA chemische Informationen	Daminozide (1596-84-5)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	40
S-Sätze:	36/37-24/25
RIDADR	UN2811 (toxic solid, organic, n.o.s.)
WGK Germany	2
RTECS-Nr.	WM9625000
HS Code	29280000
Giftige Stoffe Daten	1596-84-5(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Daminozide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Alar is a systemic growth regulator approved in the United States for use on ornamental plants such as chrysanthemums, poinsettias, and bedding plants located in enclosed structures such as greenhouses. Alar reduces internode elongation; induces heat, drought, and frost resistance; and produces darker foliage and stronger stems as well as earlier and multiple flowers and fruits. A spray is often applied at the rate of 1500–10 000 ppm.
Chemische Eigenschaften
Daminozide is a colorless crystalline solid.
Chemische Eigenschaften
white crystalline powder
Verwenden
Alar is a systemic agent (i.e., taken up by the fruit) and cannot be removed by washing or peeling.
Verwenden
Plant cell culture, tested.
Verwenden
Daminozide is a plant growth regulator used to improve crop quality and maximize yield.Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
Verwenden
Plant growth regulator.
Definition
ChEBI: Daminozide is a straight-chain fatty acid.
Allgemeine Beschreibung
Odorless white crystals or powder.
Air & Water Reaktionen
Slightly soluble in water.
Reaktivität anzeigen
Daminozide may be heat sensitive. Incompatible with strong oxidizing agents, strong acids, and bases. Also incompatible with wetting agents, alkaline materials, oils and copper-containing compounds. May corrode metals . May generate toxic gases with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. May generate flammable gases with alkali metals. Explosive reactions can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.
Brandgefahr
Flash point data for Daminozide are not available; however, Daminozide is probably combustible.
Landwirtschaftliche Anwendung
Plant growth regulator: Daminozide is a systemic growth regulator registered for use on ornamentals, including potted chrysanthemums and poinsettias, and bedding plants in enclosed structures. U.S. sales for food and feed crops were halted in 1989 because of health considerations, i. e., the Alar scare on apples.
Handelsname
ALAR®; ALAR-85®; AMINOZID®; AMINOZIDE®; B-9®; B-995®; B-NINE®; DAZIDE®; DAZIDE®; ENHANCE®; DIMAS®; KYLAR®; SADH®
Sicherheitsprofil
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx
mögliche Exposition
Daminozide is a herbicide/plant growth regulator used on certain fruit (especially apples) to improve the balance between growth and fruit production and to improve fruit quality and synchronize maturity. A RUP. United States sales were suspended in 1989 due to health considerations.
Erste Hilfe
Skin Contact: Flood all areas of body that havecontacted the substance with water. Do not wait to removecontaminated clothing; do it under the water stream. Use soapto help assure removal. Isolate contaminated clothing whenremoved to prevent contact by others. Eye Contact: Removeany contact lenses at once. Flush eyes well with copious quantities of water or normal saline for at least 2030 min. Seekmedical attention. Inhalation: Leave contaminated area immediately; breathe fresh air. Proper respiratory protection must besupplied to any rescuers. If coughing, difficult breathing, orany other symptoms develop, seek medical attention at once,even if symptoms develop many hours after exposure.Ingestion: If convulsions are not present, give a glass or two ofwater or milk to dilute the substance. Assure that the person’sairway is unobstructed and contact a hospital or poison centerimmediately for advice on whether or not to induce vomiting.
Stoffwechselwegen
Daminozide is oxidized by photochemically generated singlet oxygen, with rose bengal as a sensitizing agent in methanol-d4 to yield equimolar amounts of N,N- dimethylnitrosamine (DMN) and succinic anhydride as the only products detected by 1H and 13C NMR. The reaction is efficiently inhibited by 2,5-dimethylfuran as a competitor for, or sodium azide as a quencher of, singlet oxygen. Humic acid, similar to that found in natural and waste waters, and a red pigment isolated from apple peel also sensitize the photodegradation of daminozide to produce DMN and succinic anhydride.
Lager
Room temperature
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Toxicity evaluation
Alar does not degrade following contact with water but degrades rapidly in soil resulting in volatile compounds (including formaldehyde) and bound residues; therefore mobility is not considered a concern. In greenhouse studies, alar persistence ranged from 3 to 4 days in different soils. Since alar is registered for greenhouse use only, agricultural runoff into groundwater is not expected to be a concern.
Inkompatibilitäten
Daminozide may be heat sensitive. Incompatible with strong oxidizing agents, strong acids, and bases. Also incompatible with wetting agents, alkaline materials, oils and copper-containing compounds. May corrode metals (NTP, 1992). May generate toxic gases with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and reducing agents. May generate flammable gases with alkali metals. Explosive reactions can occur with strong oxidizing agents, metal salts, peroxides, and sulfides . Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithio- nites (releasing hydrogen sulfate and oxides of sulfur).
Einzelnachweise
1) Rose et al. (2012), Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone methylases; J. Med. Chem., 55 6639 2) Chen et al. (2016),?Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1; Oncotarget, 7 27689

Daminozide Upstream-Materialien And Downstream Produkte

Daminozid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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