AM 630 Struktur

AM 630

Bezeichnung:AM 630

CAS-Nr164178-33-0

Englisch Name:AM 630

CBNumberCB5731721

SummenformelC23H25IN2O3

Molgewicht504.36

MOL-Datei164178-33-0.mol

AM 630 physikalisch-chemischer Eigenschaften

Siedepunkt	605.9±55.0 °C(Predicted)
Dichte	1.49±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: >5mg/mL
pka	6.98±0.10(Predicted)
Aggregatzustand	powder
Farbe	white to beige

Sicherheit

Kennzeichnung gefährlicher	N
R-Sätze:	50
S-Sätze:	61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

Gefahreninformationscode (GHS)

AM 630 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
AM630 has been used:
- as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from?Trametes versicolor (TPSP).
- as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells.
- as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts.
Verwenden
AM 630 acts as a potential CB2 receptor cannabinoid antagonist with application towards human lung cancer treatment and angiogenesis induction.
Definition
ChEBI: [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-3-indolyl]-(4-methoxyphenyl)methanone is a N-acylindole.
Biologische Aktivität
CB 2 antagonist/inverse agonist (K i = 31.2 nM) that displays 165-fold selectivity over CB 1 receptors. Behaves as a weak partial/inverse agonist at CB 1 receptors.
Biochem/physiol Actions
AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).
Lager
Desiccate at +4°C
Einzelnachweise
1. ross r a, brockie h c, stevenson l a, et al. agonist-inverse agonist characterization at cb1 and cb2 cannabinoid receptors of l759633, l759656 and am630. british journal of pharmacology, 1999, 126(3): 665-672. 2. patil m, patwardhan a, salas m m, et al. cannabinoid receptor antagonists am251 and am630 activate trpa1 in sensory neurons. neuropharmacology, 2011, 61(4): 778-788.

AM 630 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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