Methylmalonsaeure

Bezeichnung:Methylmalonsaeure

Englisch Name:2-Methylpropanedioic acid

CBNumberCB5713714

SummenformelC4H6O4

Molgewicht118.09

Synonyma

Methylmalonsaeure

Methylmalonsaeure physikalisch-chemischer Eigenschaften

Schmelzpunkt	128-130 °C (lit.)
Siedepunkt	272.71°C (rough estimate)
Dichte	1.45
Brechungsindex	1.4304 (estimate)
Flammpunkt	2℃
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Crystalline Powder
pka	3.07, 5.76(at 25℃)
Farbe	White
Wichte	1.455
PH	3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution)
Wasserlöslichkeit	soluble
BRN	1756084
CAS Datenbank	516-05-2(CAS DataBase Reference)
NIST chemische Informationen	Methylmalonic acid(516-05-2)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn,F
R-Sätze:	36/37/38-36-20/21/22-11
S-Sätze:	26-36/37-16
RIDADR	UN 1648 3 / PGII
WGK Germany	3
RTECS-Nr.	OO1400000
HS Code	29171900

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white crystalline powder
Verwenden
Methylmalonic acid can be used as a substrate in:
- Esterification reactions by various catalysts.
- Synthesis of pyrimidinium betaines with formamidine.
- Synthesis of malonic acid half thioester (MAHT).
Verwenden
2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
Definition
ChEBI: A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Biologische Funktion
Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.
Allgemeine Beschreibung
Methylmalonic acid is an indicator of vitamin B₁₂ deficiency and methylmalonic acidemia. This Certified Spiking Solution^? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.
Lager
Store at RT
läuterung methode
The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]