H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  (Arg)9 (Nona-L-arginine; Peptide R9) is a cell-permeable polypeptide with IC50 value of 0.78 μM for neuroprotection in a glutamate model experimental model.

• in vitro

  Poly-arginine (eg (Arg)9) and arginine-rich peptides (eg TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. It provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC ₅₀ =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC ₅₀ =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC ₅₀ =6 μM).

• in vivo

  (Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after reduces permanent middle cerebral artery occlusion (MCAO) infarct volume .

• target

  IC50: 0.78 μM (neuroprotection)

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(78)Suppliers