4-Chlor-3-methylphenol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

  H317：Kann allergische Hautreaktionen verursachen.

  H335：Kann die Atemwege reizen.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

4-Chloro-3-methylphenol Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  WEISSE ODER LEICHT ROSAFARBENE, HYGROSKOPISCHE KRISTALLE ODER KRISTALLINES PULVER.

• CHEMISCHE GEFAHREN

  Zersetzung beim Verbrennen unter Bildung giftiger und ätzender Rauche mit Chlorwasserstoff und Phosgen.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt (ACGIH 2005).
  MAK: IIb (nicht festgelegt, aber Informationen vorhanden) Sensibilisierung der Haut; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt Augen, Haut und Atemwege.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Wiederholter oder andauernder Hautkontakt kann zu Hautsensibilisierung führen.

• LECKAGE

  Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
  R41:Gefahr ernster Augenschäden.
  R43:Sensibilisierung durch Hautkontakt möglich.
  R50:Sehr giftig für Wasserorganismen.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.
  R38:Reizt die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7:Behälter dicht geschlossen halten.
  S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).

• Chemische Eigenschaften

  Colorless or almost colorless, dimorphous crystals or crystalline powder with a characteristic phenolic odor.

• Chemische Eigenschaften

  White (pure) or pink crystalline solid. Crystals turn pink on exposure to air and light. Phenolic odor.

• Chemische Eigenschaften

  white or pink crystals

• Physikalische Eigenschaften

  Colorless, white, or pinkish crystals with a slight phenolic odor. On exposure to air it slowly becomes light brown.

• Verwenden

  Disinfectant; pharmaceutic aid (preservative).

• Verwenden

  antiinfectant

• Verwenden

  4-Chloro-3-methylphenol has been used in paint formulations.

• Verwenden

  P-chloro-m-cresol is used as a preservative in a wide number of topical preparations and is a rare cause of allergic contact dermatitis and CoU, the mechanism of which remains uncertain.

• Vorbereitung Methode

  Chlorocresol is prepared by the chlorination of m-cresol.

• Definition

  ChEBI: 4-chloro-m-cresol is a hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist. It has a role as a ryanodine receptor agonist, an antimicrobial agent and a disinfectant. It is a hydroxytoluene and a member of monochlorobenzenes.

• Allgemeine Beschreibung

  A pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.

• Air & Water Reaktionen

  Hygroscopic. Soluble in aqueous base.

• Reaktivität anzeigen

  4-Chloro-3-methylphenolS are incompatible with bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys .

• Hazard

  Irritant to skin.

• Health Hazard

  Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

• Brandgefahr

  Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

• Pharmazeutische Anwendungen

  Chlorocresol is used as an antimicrobial preservative in cosmetics and pharmaceutical formulations. It is generally used in concentrations up to 0.2% in a variety of preparations except those intended for oral administration or that contact mucous membrane. Chlorocresol is effective against bacteria, spores, molds, and yeasts; it is most active in acidic media. Preservative efficacy may be reduced in the presence of some other excipients, particularly nonionic surfactants.

• Kontakt-Allergie

  Chlorocresol is a biocide used for its disinfectant and preservative properties, in topicals or cutting fluid.

• Nebenwirkungen

  Chlorocresol is used as a preservative in a variety of topical preparations, such as corticosteroid creams and moisturizers and in disinfectants and detergents. Three case reports implicate chlorocresol as a cause of Cou; however, whether this is due to an immunological cause is uncertain.
  Walker et al. report a patient who experienced localized Cou to a number of topical medicaments and moisturizers within 30 minutes of application. Patch tests of chlorocresol and her own preparations containing chlorocresol applied for just 30 minutes produced marked urticarial responses.
  A woman working in an aviary developed eyelid edema and erythema every time she used two specific disinfectants. Open and skin prick testing to 10%, but not 1%, chlorocresol was positive in this case and negative in 10 controls. This patient also experienced eyelid involvement as well as local reactions to the testing, both with superficial necrosis. Freitas et al. acknowledged that it was unusual on both aspects: for such a high concentration to be required to elicit an urticarial reaction and for superficial necrosis to occur.
  A case of simultaneous delayed and immediate hypersensitivity has also been reported. Goncalo et al. report a 35-year-old laboratory worker exposed to chlorocresol in both detergents and corticosteroid creams. Patch testing was positive and the patient was diagnosed with allergic contact dermatitis to chlorocresol, which was present in numerous products. Open and skin prick testing to 1% and 5% chlorocresol were positive after 20 minutes. Ten controls were also tested, all were negative to the 1% formulation, although six were positive to 5%,[48] suspicious for a nonimmunological Cou.

• Sicherheitsprofil

  Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An allergen. Mutation data reported. Incompatible with sodium hydroxide. When heated to decomposition it emits toxic fumes of Cl and phosgene. See also CRESOL and CHLOROPHENOLS.

• Sicherheit(Safety)

  Chlorocresol is used primarily as a preservative in topical pharmaceutical formulations but has also been used in nebulized solutions and ophthalmic and parenteral preparations. It should not, however, be used in formulations for intrathecal, intracisternal, or peridural injection.
  Chlorocresol is metabolized by conjugation with glucuronic acid and sulfate and is excreted in the urine, mainly as the conjugate, with little chlorocresol being excreted unchanged. Although less toxic than phenol, chlorocresol may be irritant to the skin, eyes, and mucous membranes, and has been reported to cause some adverse reactions when used as an excipient.
  Sensitization reactions may follow the prolonged application of strong solutions to the skin, although patch tests have shown that chlorocresol is not a primary irritant at concentrations up to 0.2%. Chlorocresol is recognized as a rare cause of allergic contact dermatitis. Cross sensitization with the related preservative chloroxylenol has also been reported. At concentrations of 0.005% w/v, chlorocresol has been shown to produce a reversible reduction in the ciliary movement of human nasal epithelial cells in vitro, and at concentrations of 0.1% chlorocresol produces irreversible ciliostasis; therefore it should be used with caution in nasal preparations. However, a clinical study in asthma patients challenged with chlorocresol or saline concluded that preservative might be used safely in nebulizer solution.
  Chlorocresol is approved as safe for use in cosmetics in Europe at a maximum concentration of 0.2%, although not in products intended to come in contact with mucous membranes.
  Chlorocresol at a concentration as low as 0.05% produces ocular irritation in rabbits. Despite such reports, chlorocresol has been tested in ophthalmic preparations.
  When used systemically, notably in a heparin injection preserved with chlorocresol 0.15%, delayed irritant and hypersensitivity reactions attributed to chlorocresol have been reported.
  LD₅₀ (mouse, IV): 0.07 g/kg
  LD₅₀ (mouse, oral): 0.6 g/kg
  LD₅₀ (mouse, SC): 0.36 g/kg
  LD₅₀ (rabbit, dermal): >5 g/kg
  LD₅₀ (rat, dermal): >2 g/kg
  LD₅₀ (rat, oral): 1.83 g/kg
  LD₅₀ (rat, SC): 0.4 g/kg

• mögliche Exposition

  Chlorinated phenol fungicide, microbiocide, and germicide used to control bacteria, yeasts, and fungi.

• Environmental Fate

  Biological. When p-chloro-m-cresol was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, significant biodegradation with rapid adaptation was observed. At concentrations of 5 and 10 mg/L, 78 and 76% biodegradation, respectively, were observed after 7 d (Tabak et al., 1981).
  Chemical/Physical. At influent concentrations (pH 3.0) of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 122, 63, 32, and 17 mg/g, respectively. At pH 5.5 and pH 9.0 at influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 124, 85, 58, and 40 mg/g and 99, 38, 15, and 5.5 mg/g, respectively (Dobbs and Cohen, 1980).

• Lager

  Chlorocresol is stable at room temperature but is volatile in steam. Aqueous solutions may be sterilized by autoclaving. On exposure to air and light, aqueous solutions may become yellow colored. Solutions in oil or glycerin may be sterilized by heating at 1608℃ for 1 hour. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.

• Versand/Shipping

  UN2669 Chlorocresols solution, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3437 Chlorocresols solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• läuterung methode

  Crystallise the phenol from pet ether or *C6H6. [Beilstein 6 H 381, 6 I 187, 6 II 355, 6 III 1315, 6 IV 2064.]

• Inkompatibilitäten

  Chlorocresols react with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Contact with oxidizing agents may cause a fire and explosion hazard. Heat produces phosgene, hydrogen chloride and chlorine gases. Corrosive to aluminum, copper, tin, and other chemically active metals.

• Inkompatibilitäten

  Chlorocresol can decompose on contact with strong alkalis, evolving heat and fumes that ignite explosively. It is also incompatible with oxidizing agents, copper, and with solutions of calcium chloride, codeine phosphate, diamorphine hydrochloride, papaveretum, and quinine hydrochloride. Chlorocresol is corrosive to metals and forms complex compounds with transition metal ions; discoloration occurs with iron salts. Chlorocresol also exhibits strong sorption or binding tendencies to organic materials such as rubber, certain plastics, and nonionic surfactants.
  Chlorocresol may be lost from solutions to rubber closures, and in contact with polyethylene may initially be rapidly removed by sorption and then by permeation, the uptake being temperature dependent. Presoaking of components may reduce losses due to sorption, but not those by permeation. Chlorocresol may also be taken up by polymethylmethacrylate and by cellulose acetate. Losses to polypropylene or rigid polyvinyl chloride are usually small.
  At a concentration of 0.1%, chlorocresol may be completely inactivated in the presence of nonionic surfactants, such as polysorbate 80. However, other studies have suggested an enhancement of antimicrobial properties in the presence of surfactants. Bactericidal activity is also reduced, due to binding, by cetomacrogol, methylcellulose, pectin, or cellulose derivatives. In emulsified or solubilized systems, chlorocresol readily partitions into the oil phase, particularly into vegetable oils, and higher concentrations will be required for efficient preservation.

• Waste disposal

  A good candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.

• Regulatory Status

  Included in the FDA Inactive Ingredients Database (topical creams and emulsions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
  In Europe, chlorocresol is approved for use in cosmetics at a maximum concentration of 0.2%; however, it is prohibited for use in products intended to come into contact with mucous membranes. In Japan, use of chlorocresol in cosmetics is restricted to a level of 0.5 g/100 g.

4-Chloro-3-methylphenol Upstream-Materialien And Downstream Produkte

4-Chlor-3-methylphenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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