beta-Cyclodextrin methyl ethers

Bezeichnung:beta-Cyclodextrin methyl ethers

CAS-Nr128446-36-6

Englisch Name:beta-Cyclodextrin methyl ethers

CBNumberCB5696215

SummenformelC54H94O35

Molgewicht1303.3

MOL-Datei128446-36-6.mol

beta-Cyclodextrin methyl ethers physikalisch-chemischer Eigenschaften

Schmelzpunkt	180-182 °C(lit.)
alpha	+159°(25℃, c=1, H2O)
Flammpunkt	187 °C
storage temp.	room temp
Löslichkeit	H2O: soluble50mg/mL
Aggregatzustand	powder
Farbe	White to off-white
Optische Aktivität	[α]25/D +159°, c = 1 in H2O
Biologische Quelle	synthetic (organic)
Wasserlöslichkeit	Soluble in water
InChIKey	YZOUYRAONFXZSI-SBHWVFSVSA-N
LogP	-2.566 (est)
EPA chemische Informationen	.beta.-Cyclodextrin, methyl ethers (128446-36-6)
Absorption	≤0.10 at 350-600nm in solution at 10% ≤1.00 at 220-350nm in solution at 10%

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
TSCA	Yes
HS Code	35051000

Gefahreninformationscode (GHS)

beta-Cyclodextrin methyl ethers Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Chemische Eigenschaften
White powder
Verwenden
Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.
Verwenden
Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts.
Verwenden
substrate for laminarinase and other glucanases
Allgemeine Beschreibung
Methyl-β-cyclodextrin is a small cyclic heptasaccharide.
Biochem/physiol Actions
Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.

beta-Cyclodextrin methyl ethers Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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