CP-154,526

CP-154,526 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

• Biologische Aktivität

  Selective, non-peptide CRF 1 receptor antagonist (K i values are 2.7 and > 10000 nM for CRF 1 and CRF 2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (K i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

CP-154,526 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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