β-Glycerophosphate disodium salt pentahydrate

Bezeichnung:β-Glycerophosphate disodium salt pentahydrate

CAS-Nr13408-09-8

Englisch Name:β-Glycerophosphate disodium salt pentahydrate

CBNumberCB5502680

SummenformelC3H12NaO7P

Molgewicht214.09

MOL-Datei13408-09-8.mol

β-Glycerophosphate disodium salt pentahydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300°C
storage temp.	2-8°C
Löslichkeit	H₂O: 0.1 g/mL, clear, colorless
Aggregatzustand	White powder
Farbe	Whiteto Off-White
Wasserlöslichkeit	Soluble in water.
Merck	14,8622
BRN	3744328
Stabilität	Hygroscopic
InChI	InChI=1S/C3H9O6P.Na.H2O.H/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;1H2;
InChIKey	PEMUISUYOHQFQH-UHFFFAOYSA-L
SMILES	O(P(O)(O)=O)C(CO)CO.[NaH].O

Sicherheit

WGK Germany	3
RTECS-Nr.	UA0600000
F	10-21
TSCA	Yes
HS Code	29199000

Gefahreninformationscode (GHS)

β-Glycerophosphate disodium salt pentahydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
β-Glycerophosphate is a protein phosphatase inhibitor that acts as a phosphate group donor in matrix mineralization studies. It promotes bone matrix mineralization when delivered to osteoblasts by providing a source of phosphate ions. β-Glycerophosphate (10 mM) accelerates calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism.
Chemische Eigenschaften
Solid
Verwenden
Sodium β-glycerophosphate pentahydrate is used as a phosphatase inhibitor. It promotes bone matrix mineralization while delivering to osteoblasts by providing a source of phosphate ions. It is used in the development of hydrogels and scaffolds, which finds applications in tissue engineering and cell growth. It is used as an additive in isolation mediums by providing phosphate ions to isolate. It is utilized to promote mineralization in vitro by modulating bone cell metabolic activity.
Verwenden
β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions.
Allgemeine Beschreibung
A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Also acts as a protein phosphatase inhibitor.
Biochem/physiol Actions
Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression
läuterung methode
Crystallise it from water. [Attwood et al. Biochem J 253 389 1988, Beilstein 1 IV 2766.]
Einzelnachweise
[1]. chung ch, golub ee, forbes e, et al. mechanism of action of beta-glycerophosphate on bone cell mineralization. calcif tissue int. 1992 oct;51(4):305-11.
[2]. fujimoto h, mabuchi i. isolation of cleavage furrows from eggs of regular sea urchins and identification of furrow-specific proteins. j biochem. 1997 sep;122(3):518-24.
[3]. lecanda f, avioli lv, cheng sl. regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. j cell biochem. 1997 dec 1;67(3):386-96.
[4]. shioi a, nishizawa y, jono s, et al. beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. arterioscler thromb vasc biol. 1995 nov;15(11):2003-9.

β-Glycerophosphate disodium salt pentahydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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