(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID

Bezeichnung:(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID

CAS-Nr54699-92-2

Englisch Name:(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID

CBNumberCB5494642

SummenformelC7H14N2O2

Molgewicht158.2

MOL-Datei54699-92-2.mol

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	130-133°C
Siedepunkt	278℃
Dichte	1.123
Flammpunkt	122℃
storage temp.	Sealed in dry,Room Temperature
pka	1.85±0.10(Predicted)
Aggregatzustand	solid
Farbe	Off-white
InChI	InChI=1S/C7H14N2O2/c1-8-2-4-9(5-3-8)6-7(10)11/h2-6H2,1H3,(H,10,11)
InChIKey	JCXZKUZXVQKENT-UHFFFAOYSA-N
SMILES	N1(CC(O)=O)CCN(C)CC1
CAS Datenbank	54699-92-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-41-37/38
S-Sätze:	26-36/37/39-39
HazardClass	IRRITANT
HS Code	2933599590

Gefahreninformationscode (GHS)

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
(Carboxymethyl)-N''-methylpiperazine acts as a potential antibacterial compound, due to its nocathiacin analog.
Verwenden
(Carboxymethyl)-N'-methylpiperazine acts as a potential antibacterial compound, due to its nocathiacin analog.
Synthese

28920-67-4

54699-92-2

b) Synthesis of 4-methyl-1-piperazinylacetic acid Ethyl (4-methyl-1-piperazinyl) acetate (1.3 g, 6.50 mmol, 1.0 eq.) was dissolved in 8N hydrochloric acid and the reaction was stirred at 95°C for 16 hours. After completion of the reaction, the reaction solution was concentrated by vacuum rotary evaporator. The remaining hydrochloric acid was neutralized with sodium bicarbonate solution and subsequently extracted with ethyl acetate (3 x 10 ml). The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The organic solvent was removed by distillation under reduced pressure to afford the target product 4-methyl-1-piperazineacetic acid in 54.5% yield (0.6 g).LC-MS (ESI) analysis: theoretical mass: 158.0; measured mass: 159.1 [M + H]+ (retention time: 0.102 min).
Einzelnachweise
[1] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 8, p. 1489 - 1494
[3] Patent: EP2107054, 2009, A1. Location in patent: Page/Page column 26

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Upstream-Materialien And Downstream Produkte

(4-METHYL-PIPERAZIN-1-YL)-ACETIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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