ZT-12-037-01 Struktur

ZT-12-037-01

Bezeichnung:ZT-12-037-01

Englisch Name:ZT-12-037-01

CBNumberCB54927142

SummenformelC21H31N5O2

Molgewicht385.5

ZT-12-037-01 physikalisch-chemischer Eigenschaften

Gefahreninformationscode (GHS)

Biologische Aktivität
ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.
in vitro

Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.
in vivo

ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.

target

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