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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Struktur

Levomepromazin

Bezeichnung:Levomepromazin

CAS-Nr60-99-1

Englisch Name:(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

CBNumberCB5488571

SummenformelC19H24N2OS

Molgewicht328.47

MOL-Datei60-99-1.mol

Synonyma

Levomepromazin

Levomepromazin physikalisch-chemischer Eigenschaften

Schmelzpunkt	117°C
Siedepunkt	468.0±45.0 °C(Predicted)
Dichte	1.0897 (rough estimate)
Brechungsindex	1.5950 (estimate)
storage temp.	Store at -20°C
Löslichkeit	Chloroform (Slightly), Methanol (Very Slightly)
Aggregatzustand	Solid
pka	9.32±0.28(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	20mg/L(25 ºC)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	36
RIDADR	3249
RTECS-Nr.	SO6125000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2934302300
Toxizität	LD50 oral in rat: 1100mg/kg

Gefahreninformationscode (GHS)

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Originator
Levoprome ,Lederle,US,1966
Verwenden
(R)-Methotrimeprazine acts as an analgesic agent.
Definition
ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.
Manufacturing Process
95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.
Trademarks
Levoprome (Immunex).
Therapeutic Function
Analgesic

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Upstream-Materialien And Downstream Produkte

Levomepromazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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