2,4-Dihydroxybenzophenon

Bezeichnung:2,4-Dihydroxybenzophenon

CAS-Nr131-56-6

Englisch Name:2,4-Dihydroxybenzophenone

CBNumberCB5475441

SummenformelC13H10O3

Molgewicht214.22

MOL-Datei131-56-6.mol

Synonyma

2,4-Dihydroxybenzophenon

2,4-Dihydroxybenzophenon physikalisch-chemischer Eigenschaften

Schmelzpunkt	144.5-147 °C(lit.)
Siedepunkt	194 °C (1 mmHg)
Dichte	1,32 g/cm³
Dampfdruck	0Pa at 25℃
Brechungsindex	1.5090 (estimate)
Flammpunkt	125 °C
storage temp.	Store below +30°C.
Löslichkeit	Chloroform (Slightly, Heated), Ethanol (Slightly, Heated)
pka	7.72±0.35(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	Yellow
PH	5 (10g/l, H2O, 20℃)(slurry)
Wasserlöslichkeit	insoluble
Merck	14,1106
BRN	1311566
InChIKey	ZXDDPOHVAMWLBH-UHFFFAOYSA-N
LogP	2.964 at 25℃
CAS Datenbank	131-56-6(CAS DataBase Reference)
NIST chemische Informationen	Methanone, (2,4-dihydroxyphenyl)phenyl-(131-56-6)
EPA chemische Informationen	Methanone, (2,4-dihydroxyphenyl)phenyl- (131-56-6)

Sicherheit

Kennzeichnung gefährlicher	Xi,T
R-Sätze:	36-36/37/38-61
S-Sätze:	26-37/39-45-53
WGK Germany	2
RTECS-Nr.	DJ0700000
Hazard Note	Irritant
TSCA	Yes
HS Code	29145000
Giftige Stoffe Daten	131-56-6(Hazardous Substances Data)
Toxizität	LD50 orally in Rabbit: > 5000 mg/kg

Gefahreninformationscode (GHS)

2,4-Dihydroxybenzophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
2,4-Dihydroxybenzophenone (DHP) is an organic compound derived from Garcinia xanthochymus, but there have been no reports on its biochemical functions and bioavailability. 2,4-dihydroxybenzophenone has been prepared by reacting resorcinol with benzoyl chloride or benzoic acid under anhydrous conditions in the presence of Friedel-Crafts catalysts such as AlCl3 or ZnCl2[1].
Chemische Eigenschaften
yellow crystalline powder
Verwenden
Novel mordent and disperse azo dyes were prepared by the coupling of various diazo solutions of aromatic amines with 2, 4-dihydroxybenzophenone. The ultraviolet absorbing monomers were synthesized by reaction of 2, 4-dihydroxybenzophenone with glycidyl acrylate and glycidyl methacrylate. Two new polymerizable stabilizers, 4-benzoyl-2-(α-piperidino-2-chlorobenzyl)-3-hydroxyphenyl acrylate (BPBHA) and corresponding methacrylate (BPBHMA), were synthesized and characterized from 2,4-Dihydroxybenzophenone. a polymerizable UV-stabilizer, 2-hydroxy-4-(3-methacryloxy-2-hydroxylpropoxy) benzophenone (BPMA), was synthesized using 2, 4-dihydroxybenzophenone (UV-0) and glycidyl methacrylate (GMA).
Verwenden
Ultraviolet light absorber, especially in paints and plastics.
Verwenden
2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.
Definition
ChEBI: 2,4-Dihydroxybenzophenone is a member of benzophenones.
synthetische
Obtained by condensation of benzanilide with resorcinol in the presence of zinc chloride and phosphorous oxychloride at 130–140° for 1 h (25%).
Biologische Aktivität
2,4-Dihydroxybenzophenone has potential effects on the stimulation of osteoblast differentiation and mitigate PDS-induced osteoporosisthrough the activation of the β-catenin pathway. Moreover, 2,4-Dihydroxybenzophenone demonstrated a capacity to enhance the expression of crucial osteogenic markers, including RUNX2, OSX, and ALP[2].
Kontakt-Allergie
BZP-1 is used, for example, in paints, plastics, and nail varnishes.
Sicherheitsprofil
Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Toxikologie
As a persistent and bioaccumulative compound, 2,4-Dihydroxybenzophenone (BP-1) exhibits estrogenic activity or anti-androgenic activity in vitro, which could pose potential risks to the ecological environment and human health. At present, there are a large amount of reports that concentrated on the biotoxicity of BP-1, mainly focusing on its endocrine disrupting effects and genetic toxicity. Endocrine-toxicological studies have shown that the toxicity of BP-1 is five times that of bisphenol A (BPA)[2].
läuterung methode
Recrystallise it from MeOH. [Beilstein 8 IV 2442.]
Einzelnachweise
[1] Mengting Zou . “Effective degradation of 2,4-dihydroxybenzophenone by zero–valent iron powder (Fe0)-activated persulfate in aqueous solution: Kinetic study, product identification and theoretical calculations.” Science of the Total Environment 771 (2021): Article 144743.
[2] Mirissa Hewage Dumindu Kavinda and & Gi-Young Kim*. “2,4′-Dihydroxybenzophenone Exerts Bone Formation and Antiosteoporotic Activity by Stimulating the β-Catenin Signaling Pathway.” ACS Pharmacology and Translational Science 7 2 (2024): 395–405.

2,4-Dihydroxybenzophenone Upstream-Materialien And Downstream Produkte

2,4-Dihydroxybenzophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

131-56-6, 2,4-Dihydroxybenzophenone Verwandte Suche:

Send Inquriy