Trimethylsilyl-2,2,2-trifluoro-N-(trimethylsilyl)acetimidat

Bezeichnung:Trimethylsilyl-2,2,2-trifluoro-N-(trimethylsilyl)acetimidat

CAS-Nr25561-30-2

Englisch Name:Bis(trimethylsilyl)trifluoroacetamide

CBNumberCB5464744

SummenformelC8H18F3NOSi2

Molgewicht257.4

MOL-Datei25561-30-2.mol

Synonyma

Trimethylsilyl-2,2,2-trifluoro-N-(trimethylsilyl)acetimidat

Trimethylsilyl-2,2,2-trifluoro-N-(trimethylsilyl)acetimidat physikalisch-chemischer Eigenschaften

Schmelzpunkt	-10°C
Siedepunkt	45-50 °C14 mm Hg(lit.)
Dichte	0.97 g/mL(lit.)
Brechungsindex	n20/D 1.384(lit.)
Flammpunkt	75 °C
storage temp.	2-8°C
Löslichkeit	Miscible with chloroform.
Aggregatzustand	Liquid
pka	1.82±0.50(Predicted)
Wichte	0.971
Farbe	Colorless to pale yellow
Wasserlöslichkeit	hydrolyses
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Sensitive	Moisture Sensitive
BRN	3607620
Stabilität	Moisture Sensitive
InChIKey	XCOBLONWWXQEBS-KPKJPENVSA-N
CAS Datenbank	25561-30-2(CAS DataBase Reference)
NIST chemische Informationen	Bis(trimethylsilyl)trifluoroacetamide(25561-30-2)

Sicherheit

Kennzeichnung gefährlicher	C,F,T
R-Sätze:	11-34-10-35-14
S-Sätze:	26-36/37/39-45-16
RIDADR	UN 2924 3/PG 3
WGK Germany	3
F	10-21
Hazard Note	Flammable/Moisture Sensitive
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29310095

Gefahreninformationscode (GHS)

Bis(trimethylsilyl)trifluoroacetamide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R34:Verursacht Verätzungen.
R10:Entzündlich.
R35:Verursacht schwere Verätzungen.
R14:Reagiert heftig mit Wasser.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S16:Von Zündquellen fernhalten - Nicht rauchen.
Chemische Eigenschaften
Clear to yellowish clear liquid
Verwenden
Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.
Verwenden
N,O-bis(trimethylsilyl)-trifluoroacetamide (BSTFA) is similar to BSA in specificity of modification and there are several studies which have used both reagents.One study found BSTFA superior to BSA in product stability and yield of derivative. Another study compared several trimethylsilyl donors for end-capping of silica and observed that BSTFA was more reactive than BSA but less reactive than TMCim. Both BSA and BSTFA were used to prepare trimethylsilyl derivatives of pyrimidines and purines.Current work has used BSTFA for metabolomics analysis of urine,for the measurement of khatamines (psychoactive amines of khat (Catha edulis Forsk), and for the measurement of acrylamide in cocoa.
Verwenden
N,O-Bis(trimethylsilyl)trifluoroacetamide is used for analytical purposes or as a chemical reagent for synthesis of more complex molecules. It is silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions. It is also used as DAT inhibitor and a SLC6A2 inhibitor. It is routinely used to derivatize carboxylic acids, phenols, steroids, amines, alcohols, and alkaloids and amides.
Definition
ChEBI: A silyl ether that is the N,O-bis(trimethylsilyl) derivative of trifluoroacetamide. N,O-bis(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/m ss spectrometry applications.
Allgemeine Beschreibung
N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). It can also be used in HPLC- electrochemical detection assay of 8-oxo-deoxyguanosine and?8-oxo-guanine.

Bis(trimethylsilyl)trifluoroacetamide Upstream-Materialien And Downstream Produkte

Trimethylsilyl-2,2,2-trifluoro-N-(trimethylsilyl)acetimidat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

25561-30-2, Bis(trimethylsilyl)trifluoroacetamide Verwandte Suche:

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