ANTI-PERILIPIN A

ANTI-PERILIPIN A Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Anti-Perilipin A antibody produced in rabbit has also been used in:
  
  • indirect immunofluorescence
  • immunoblotting
  • immunohistochemistry
  
  

• Allgemeine Beschreibung

  Perilipin is an intracellular neutral lipid storage droplet surface protein in white and brown fat adipocytes. It is also found in lower quantity coating droplets in steroidogenic-cells of the adrenal cortex, ovaries and testicular Leydig cells, on the surface of smaller droplets containing cholesteryl esters. Perilipin has multiple isoforms, resulting from differential splicing events. Perilipin A is most abundant in adipocytes and steroidogenic cells. Perilipin B is a minor form in adipocytes. Steroidogenic cells selectively express perilipins C and D.

• Biochem/physiol Actions

  Perilipin is a gatekeeper protein that is involved in regulating triacylglycerol storage in adipocyte through the suppression of basal lipolysis apparently through protecting triacylglycerol against hydrolysis. Perilipin also enhances cyclic adenosine monophosphate (c-AMP)-dependent protein kinase (PKA)-stimulated lipolysis by hormone-sensitive lipase (HSL) and non-HSLs. Perilipin knockout mice exhibit reduced adipose tissue mass and resistance to diet induced obesity. Their lipid storage droplets are coated with adipose differentiation-related protein (ADRP, adipophilin), which is not phosphorylated by PKA.

ANTI-PERILIPIN A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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