Ascomycin Struktur

Ascomycin

Bezeichnung:Ascomycin

CAS-Nr11011-38-4

Englisch Name:Ascomycin

CBNumberCB5406331

SummenformelC43H69NO12

Molgewicht792.01

MOL-Datei11011-38-4.mol

Ascomycin physikalisch-chemischer Eigenschaften

Schmelzpunkt	158 - 161°C
storage temp.	-20°C
Löslichkeit	Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
Aggregatzustand	White crystalline solid
Farbe	White
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Sicherheit

RTECS-Nr.

CI7570000

Gefahreninformationscode (GHS)

Ascomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo.
Verwenden
A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.
Allgemeine Beschreibung
An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
Biochem/physiol Actions
Product does not compete with ATP.
Enzyminhibitor
This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4; Solubility: 50 mM in DMSO), also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.
Einzelnachweise
1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729

Ascomycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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