ISOQUINOLINE-5-SULFONYL CHLORIDE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P330+P331：BEI VERSCHLUCKEN: Mund ausspülen. KEIN Erbrechen herbeiführen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

ISOQUINOLINE-5-SULFONYL CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Colourless Crystalline Solid

• Synthese

  

  27655-40-9

  

  84468-15-5

  The general procedure for the synthesis of isoquinoline-5-sulfonyl chloride from 5-isoquinolinesulfonic acid was as follows: 5-isoquinolinesulfonic acid was placed in a round-bottomed flask, 6 mL of thionyl chloride and 1 drop of N,N-dimethylformamide (DMF) were added, and the reaction was carried out at reflux for 3 hours. Upon completion of the reaction, the excess thionyl chloride was removed using a rotary evaporator. Dichloromethane (DCM) was added to the residual solid and the solid product was collected by filtration. The solid was washed three times with DCM and subsequently dried in a vacuum oven to give a white solid intermediate 2 (1 g, 91.9% yield). Intermediate 2 (130.00 mg, 571.01 μmol) was slowly added to a solution of DCM (6 mL) containing ethylenediamine (381.30 μL, 5.71 mmol) under ice-bath conditions. After removing the ice bath, the mixture was allowed to react for 3 h at room temperature. Upon completion of the reaction, the mixture was washed with water to remove the remaining ethylenediamine. The organic phase was removed using a rotary evaporator and the residue was recrystallized by ether to give brown solid 3 (91.8 mg, 60% yield).

• Einzelnachweise

  [1] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0064; 0068; 0069
  [2] Patent: CN106279136, 2017, A. Location in patent: Paragraph 0022
  [3] Patent: US5891909, 1999, A
  [4] Patent: US6235778, 2001, B1
  [5] Patent: EP906091, 2006, B1. Location in patent: Page/Page column 48

ISOQUINOLINE-5-SULFONYL CHLORIDE Upstream-Materialien And Downstream Produkte

ISOQUINOLINE-5-SULFONYL CHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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