Tetradoniumbromid

Bezeichnung:Tetradoniumbromid

CAS-Nr1119-97-7

Englisch Name:Tetradecyltrimethylammonium bromide

CBNumberCB5335152

SummenformelC17H38N.Br

Molgewicht336.39

MOL-Datei1119-97-7.mol

Synonyma

Tetradoniumbromid

Tetradoniumbromid physikalisch-chemischer Eigenschaften

Schmelzpunkt	245-250 °C(lit.)
Dichte	1.1328 (rough estimate)
Dampfdruck	0Pa at 25℃
Brechungsindex	1.5260 (estimate)
storage temp.	Store below +30°C.
Löslichkeit	H₂O: 10 % (w/v)
Aggregatzustand	Fine Crystalline Powder
Farbe	White
PH	pH (50g/l, 25℃ : 4.0～6.0
Wasserlöslichkeit	20 g/100 mL
Sensitive	Hygroscopic
maximale Wellenlänge (λmax)	λ: 240 nm Amax: ≤0.08 λ: 250 nm Amax: ≤0.05 λ: 260 nm Amax: ≤0.04 λ: 500 nm Amax: ≤0.02
Merck	14,6336
BRN	3633227
Stabilität	Stable. Hygroscopic. Incompatible with strong oxidizing agents.
InChIKey	CXRFDZFCGOPDTD-UHFFFAOYSA-M
LogP	2.2 at 20℃
CAS Datenbank	1119-97-7(CAS DataBase Reference)
EPA chemische Informationen	Tetradecyl trimethyl ammonium bromide (1119-97-7)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	26-36/37/39-45-27
RIDADR	UN 3263 8/PG 2
WGK Germany	3
RTECS-Nr.	BS5776000
F	3
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29239000
Toxizität	LD50 in mice, rats (mg/kg): 12.0, 15.0 i.v. (Issomaa, Bjondahl)

Gefahreninformationscode (GHS)

Tetradecyltrimethylammonium bromide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
Beschreibung
MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4
Verwenden
Myristyltrimethylammonium has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure.??It has also been used in a study to determine the low molecular weight of organic acids in soils and plants by capillary zone electrophoresis.
Verwenden
Disinfectant; deodorant; laboratory reagent.
Definition
Myristyltrimethylammonium bro-mide.
Allgemeine Beschreibung
Myristyltrimethylammonium bromide is a cationic/zwitterionic type of surfactant.
läuterung methode
Crystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.]
Einzelnachweise
1) Quan et al. (2007), Myristal trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecules dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II; Mol. Pharmacol., 72 1425 2) Joshi et al. (2011), Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high performance liquid chromatography; Mol. Cancer, 104 78 3) De Beco et al. (2009), Endocytosis is required for E-cadherin redistribution at mature adherens junctions; Proc. Natl. Acad. Sci. USA, 106 7010 4) Kim et al. (2016), Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells; Biochem. Biophys. Res. Commun., 478 1609

Tetradecyltrimethylammonium bromide Upstream-Materialien And Downstream Produkte

Tetradoniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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