2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent SHP-1 inhibitor with IC50 of 40 nM for recombinant SHP-1. It has anticancer activity.

• in vitro

  SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. It selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ ⁺ cells and induces IFNγ < sup> + cells in human peripheral blood.

• in vivo

  TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. It thus also increases pLck-pY394 and IFNγ ⁺ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated sc agent.

• target

  Target	Value
  SHP-1 (Cell-free assay)	40 nM

2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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