2-Desoxy-D-ribose

Bezeichnung:2-Desoxy-D-ribose

CAS-Nr533-67-5

Englisch Name:2-Deoxy-D-ribose

CBNumberCB5315585

SummenformelC5H10O4

Molgewicht134.13

MOL-Datei533-67-5.mol

Synonyma

2-Desoxy-D-ribose

2-Desoxy-D-ribose physikalisch-chemischer Eigenschaften

Schmelzpunkt	89-90 °C(lit.)
Siedepunkt	167.23°C (rough estimate)
alpha	-57 º (c=1, H2O, 24hr)
Dichte	1.0590 (rough estimate)
Brechungsindex	-56 ° (C=1, H2O)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
Aggregatzustand	Crystalline Powder
pka	12.61(at 25℃)
Farbe	White to slightly yellow
Optische Aktivität	[α]22/D 59°, c = 1 in H2O
Wasserlöslichkeit	soluble
Sensitive	Hygroscopic
Merck	14,2908
BRN	1721978
Stabilität	Hygroscopic
InChIKey	ASJSAQIRZKANQN-CRCLSJGQSA-N
CAS Datenbank	533-67-5(CAS DataBase Reference)
NIST chemische Informationen	D-Erythro-pentose, 2-deoxy-(533-67-5)
EPA chemische Informationen	D-erythro-Pentose, 2-deoxy- (533-67-5)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	24/25-37/39-36-26
WGK Germany	3
RTECS-Nr.	SB7230000
F	3-10
TSCA	Yes
HS Code	29400000

Gefahreninformationscode (GHS)

2-Deoxy-D-ribose Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
2-deoxy-D-Ribose is a reducing sugar formed as a degradation product during metabolism of thymidine by thymidine phosphorylase. It increases levels of reactive oxygen species (ROS) in HL-60 human leukemia cells when used at a concentration of 15 mM. 2-deoxy-D-Ribose (10 μM) induces tubulogenesis and migration of bovine aortic endothelial (BAE) cells. Topical administration of 2-deoxy-D-ribose increases blood vessel formation and accelerates wound healing in a rat full-thickness cutaneous wound model.
Verwenden
2-Deoxy-D-ribose (2dDR) can be used to prepare multifunctional wound dressings capable of inducing rapid angiogenesis with antimicrobial activity, such as 2dDR-SA hydrogel. The gel can be used to stimulate wound healing and treat superficial skin wounds, including chronic wound care. In addition, 2dDR gel has the potential to treat androgenetic alopecia and other causes of alopecia areata.
Verwenden
2-Deoxy-D-ribose is used as a precursor to deoxyribonucleic acid. It induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. Further, it is used in the synthesis of optically active dipyrrolyl alkanols from pyrroles on the surface of montmorillonite KSF clay.
Definition
ChEBI: 2-deoxy-D-ribose is a deoxypentose that is D-ribose in which the hydroxy group at position C-2 is replaced by hydrogen. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is functionally related to a D-ribose.
benefits
Hair Regrowth in Mice: Applying a small dose of 2-deoxy-D-ribose to mice models led to significant hair regrowth.
Blood Vessel Formation: The hair regrowth was linked to forming new blood vessels, enhancing blood supply to hair follicles.
Comparable to Minoxidil: The effectiveness of 2-deoxy-D-ribose in regrowing hair was similar to that of Minoxidil, a widely used hair loss treatment.
Biologische Aktivität
2-Deoxy-D-ribose (2dDR) is a D-isomer of a deoxypentose monosaccharide in which a hydrogen atom is present with a hydroxyl group at the C-2 position in place of the hydroxyl group. 2dDR is known to enhance tubulogenesis, prevent hypoxia-induced apoptosis, and boost VEGF and IL-8 production of ECs in vitro, consistent with the stimulatory effects of 2dDR on cell proliferation and migration. 2dDR also stimulated angiogenesis, proliferation of endothelial cells, and accelerated wound healing in rat models. Additionally, 2dDR can be loaded into several biomaterials for prolonged release over several days to promote the growth of neonatal blood vessels[1].
Einzelnachweise
[1] Anjum, Muhammad Awais et al. “Stimulation of hair regrowth in an animal model of androgenic alopecia using 2-deoxy-D-ribose.” Frontiers in Pharmacology 44 16 (2024).

2-Deoxy-D-ribose Upstream-Materialien And Downstream Produkte

2-Desoxy-D-ribose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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