5-Nonyloxytryptamine oxalate

5-Nonyloxytryptamine oxalate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT_1Dβ with an EC₅₀ value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT_1Dβ receptor. It is selective for 5-HT_1Dβ over 5-HT_1A for its adenylate cyclase activity, with an EC₅₀ greater than 1 μM for 5-HT_1A. It binds to 5-HT_1Dβ, 5-HT_1A, 5-HT_1B, 5-HT_2A, and 5-HT_2C receptors in vitro (K_is = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization.

• Verwenden

  5-Nonyloxytryptamine Oxalate is a selective 5-HT1B agonist.

• Definition

  ChEBI: 5-nonyloxytryptamine oxalate is an oxalate salt obtained by reaction of 5-nonyloxytryptamine with one equivalent of oxalic acid. 5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). It has a role as a serotonergic agonist. It contains a 5-nonyloxytryptaminium(1+).

• Biochem/physiol Actions

  Nonyloxytryptamine (5-nonyloxytryptamine) is a potent and selective 5-HT1B receptor agonist. Nonyloxytryptamine is a polysialic acid (PSA) mimick that triggers PSA-mediated functions. Nonyloxytryptamine enhances neurite outgrowth of cultured primary neurons, protects neurons from oxidative stress, enhanced Schwann cell proliferation, reduces migration of astrocytes and enhances myelination in vitro.

5-Nonyloxytryptamine oxalate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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