DBCO-PEG4-amine Struktur

DBCO-PEG4-amine

Bezeichnung:DBCO-PEG4-amine

Englisch Name:DBCO-PEG4-amine

CBNumberCB53062466

SummenformelC29H37N3O6

Molgewicht523.62

DBCO-PEG4-amine physikalisch-chemischer Eigenschaften

Siedepunkt	784.1±60.0 °C(Predicted)
Dichte	1.23±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under inert atmosphere
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	15.14±0.46(Predicted)
Aggregatzustand	Solid
Farbe	Yellow to Dark Yellow
Wasserlöslichkeit	Soluble in water.

Gefahreninformationscode (GHS)

Beschreibung
DBCO-NHCO-PEG4-amine is a carboxyl-reactive building block with extended PEG spacer arm. The hydrophilic PEG spacer arm improves water solubility. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Biologische Aktivität
DBCO-NHCO-PEG4-amine is a PROTAC linker and belongs to the PEG class. It is a cleavable ADC linker that can be used to link MMAE (HY-15162) to antibodies such as DBCO-VCpAB-MMAE and DBCO-TRX-MMAE, with EC50 for SKBR3 cells, respectively 280 nM and 22 nM).
in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs