4-bromo-N'-butylbenzohydrazide

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

4-bromo-N'-butylbenzohydrazide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  UF010 is a class I HDAC inhibitor with IC₅₀ values of 0.06, 0.1, 0.5, and 1.5 μM for HDAC3, 2, 1, and 8, respectively. It is more than 6-fold selective for these class I HDACs over any additional HDACs. UF010 is reported to inhibit cancer cell proliferation with a mean GI₅₀ value of 2.94 μM when screened against the NCI-60 panel of cancer cell lines and functions by blocking the G₁/S phase of the cell cycle.

• Verwenden

  4-Bromo-2-butylhydrazide Benzoic Acid inhibits histone deacetylases (HDAC) as potential clinical anticancer therapies.

• Einzelnachweise

  [1]. wang y, stowe rl, pinello ce, et al. identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class i histone deacetylases. chem biol, 2015, 22(2): 273-284.

4-bromo-N'-butylbenzohydrazide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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