RSV604

RSV604 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  RSV604 (A-60444), a novel benzodiazepine, is an inhibitor of respiratory syncytial virus (RSV) with EC50 of 0.86 μM. It has the potential to treat RSV-related diseases. Phase 2.

• in vitro

  RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC ₅₀ s ranging from 0.5 to 0.9 μM in plaque reduction assay.
  It (6 days) inhibits RSV-induced HEp-2 cell death, with an EC ₅₀ of 0.86 μM.
  Also RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC ₅₀ of 1.7 μM.
  RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.

• target

  Target	Value
  RSV (Cell-free assay)	0.86 μM(EC50)

RSV604 Upstream-Materialien And Downstream Produkte

RSV604 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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