N-Carboxymethyliminobis(ethylennitrilo)tetraessigsure

Bezeichnung:N-Carboxymethyliminobis(ethylennitrilo)tetraessigsure

CAS-Nr67-43-6

Englisch Name:Diethylenetriaminepentaacetic acid

CBNumberCB5303977

SummenformelC14H23N3O10

Molgewicht393.35

MOL-Datei67-43-6.mol

Synonyma

N-Carboxymethyliminobis(ethylennitrilo)tetraessigsure

N-Carboxymethyliminobis(ethylennitrilo)tetraessigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	219-220 °C (lit.)
Siedepunkt	517.84°C (rough estimate)
Dichte	1.56
Brechungsindex	1.5700 (estimate)
Flammpunkt	200 °C
storage temp.	room temp
Löslichkeit	0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka	pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
Aggregatzustand	Crystalline Powder
Farbe	White to almost white
PH	2-3 (H2O, 20℃)(saturated solution)
Wasserlöslichkeit	5 g/L (20 ºC)
Merck	14,7125
BRN	1810219
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	QPCDCPDFJACHGM-UHFFFAOYSA-N
LogP	-1.361 (est)
CAS Datenbank	67-43-6(CAS DataBase Reference)
NIST chemische Informationen	N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6)
EPA chemische Informationen	Pentetic acid (67-43-6)

Sicherheit

Kennzeichnung gefährlicher	Xi,N,Xn
R-Sätze:	36-51/53-36/37/38-20-63
S-Sätze:	26-36-61-37/39-36/37
RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS-Nr.	MB8205000
F	3
TSCA	Yes
HazardClass	9
PackingGroup	III
HS Code	29224995
Toxizität	LD50 orally in Rabbit: > 2000 mg/kg

Gefahreninformationscode (GHS)

Diethylenetriaminepentaacetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Pentetic acid occurs as a white crystalline solid and is almost odorless.
Chemische Eigenschaften
Diethylenetriaminepentaacetic acid is a solid.
Verwenden
chelating agent, diagnostic aid
Verwenden
Diethylenetriaminepentaacetic acid is used as chelating agent and forms complexes with metal ions. It finds application as a magnetic resonance imaging (MRI) contrasting agent, since it improves the image by forming a complex with a gadolinium ion. It can also be used for treatment of radioactive materials such as plutonium, americium and other actinides. It is an active component of manganese and zinc fertilizers used in agrochemical industry. It acts as a color inhibitor and is used in the production of acrylon. It is also used in soaps as a water softener.
Verwenden
Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.
Definition
ChEBI: Pentetic acid is a pentacarboxylic acid. It has a role as a copper chelator. It is a conjugate acid of a pentetate(1-).
Vorbereitung Methode
Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.
Allgemeine Beschreibung
Visit our Titration Center to learn more.
Pharmazeutische Anwendungen
Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Sicherheit(Safety)
Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route.
LD₅₀ (mouse, IP): 0.54 g/kg
LD₅₀ (mouse, oral): 4.84 g/kg
Lager
The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
läuterung methode
Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]
Inkompatibilitäten
The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
Regulatory Status
Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.

Diethylenetriaminepentaacetic acid Upstream-Materialien And Downstream Produkte

N-Carboxymethyliminobis(ethylennitrilo)tetraessigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

67-43-6, Diethylenetriaminepentaacetic acid Verwandte Suche:

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