Benidipine hydrochloride

Bezeichnung:Benidipine hydrochloride

CAS-Nr91599-74-5

Englisch Name:Benidipine hydrochloride

CBNumberCB5294563

SummenformelC28H31N3O6.HCl

Molgewicht542.02

MOL-Datei91599-74-5.mol

Benidipine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	199-201°C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	DMSO: ≥20mg/mL
pka	7.34(at 25℃)
Aggregatzustand	powder
Farbe	yellow
InChIKey	DGVVISBYHUXFIU-UHFFFAOYSA-N
CAS Datenbank	91599-74-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
RTECS-Nr.	US7975657
HS Code	2933.99.5300
Toxizität	LD50 orally in male mice: 218 mg/kg (Muto, 1988)

Gefahreninformationscode (GHS)

Benidipine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.
Beschreibung
Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC₅₀ of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.
Chemische Eigenschaften
Yellow Crystalline Powder
Originator
Kyowa Hakko (Japan)
Verwenden
A dihydropyridine calcium channel blocker. Antihypertensive.
Trademarks
Coniel
Biologische Aktivität
Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.
Sicherheitsprofil
A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.
Lager
room temperature (desiccate)

Benidipine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

91599-74-5, Benidipine hydrochloride Verwandte Suche:

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