tert-Butyl 3-oxoazetidine-1-carboxylate

Bezeichnung:tert-Butyl 3-oxoazetidine-1-carboxylate

CAS-Nr398489-26-4

Englisch Name:tert-Butyl 3-oxoazetidine-1-carboxylate

CBNumberCB5282384

SummenformelC8H13NO3

Molgewicht171.19

MOL-Datei398489-26-4.mol

tert-Butyl 3-oxoazetidine-1-carboxylate physikalisch-chemischer Eigenschaften

Schmelzpunkt	47-51 °C
Siedepunkt	251.3±33.0 °C(Predicted)
Dichte	1.174±0.06 g/cm3(Predicted)
Flammpunkt	102 °C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Chloroform (Sparingly), Dichloromethane (Slightly)
pka	-1.99±0.20(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	White to off-white
Sensitive	Moisture Sensitive/Stench
InChI	InChI=1S/C8H13NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h4-5H2,1-3H3
InChIKey	VMKIXWAFFVLJCK-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CC(=O)C1
CAS Datenbank	398489-26-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	22-37/38-41
S-Sätze:	26-39
RIDADR	UN 3335
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900

Gefahreninformationscode (GHS)

tert-Butyl 3-oxoazetidine-1-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White to light brown solid
Verwenden
1-Boc-3-azetidinone can be used for the preparation of antibacterial aminoglycoside analogs.
Verwenden
tert-Butyl 3-oxoazetidine-1-carboxylate(1-Boc-3-azetidinone) is a currently common organic intermediate. It is a key intermediate for preparing various medicaments. It can be used for preparing Janus kinase 3(JAKS), which is a useful target for immunosuppression and transplant rejection, and can be used for treating inflammatory disorders, autoimmune disorders, cancer and other diseases; also useful in the preparation of a second class of HCV protease inhibitors useful in the treatment of HCV genotype 1 infection; can also be used for preparing novel aminoglycoside compounds with antibacterial activity; bicyclic himbacine (himbacine) derivatives can be prepared which are useful as antagonists of the protease activated receptor-1 (PAR-1) and are predicted to be cannabis (CB2) receptor inhibitors, useful for the treatment of secondary prevention of Acute Coronary Syndrome (ACS), myocardial infarction or thrombotic stroke or peripheral arterial disease; bicyclic azacyclobenzylamine derivatives, such as pyridopyrimidines, can be prepared that modulate the activity of phospho-inositol 3-kinase (P13K) and are useful in the treatment of diseases associated with P13K, including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
Allgemeine Beschreibung
tert-Butyl 3-oxoazetidine-1-carboxylate is moisture sensitive and incompatible with oxidizing agents. This chemical can cause skin irritation and severe eye irritation.
Synthese
The traditional preparation method of tert-Butyl 3-oxoazetidine-1-carboxylate is mainly to oxidize the hydroxyl on an aza ring into ketone. For example: 3-azetidinium alkoxide, di-tert-butyl dicarbonate and sodium bicarbonate in dioxane: stirring the mixture of water for 15 hours to obtain 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethylethyl ester; dissolving 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethyl ethyl ester in ethanedioyl chloride and dichloromethane, adding DMSO and triethylamine, stirring at room temperature for 15 hours to obtain tert-Butyl 3-oxoazetidine-1-carboxylate.

tert-Butyl 3-oxoazetidine-1-carboxylate Upstream-Materialien And Downstream Produkte

tert-Butyl 3-oxoazetidine-1-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

398489-26-4, tert-Butyl 3-oxoazetidine-1-carboxylate Verwandte Suche:

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