Dydrogesteron

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H372：Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P273：Freisetzung in die Umwelt vermeiden.

  P314：Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen.

  P391：Verschüttete Mengen aufnehmen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Dydrogesterone Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Dydrogesterone is a synthetic progestogen that has no estrogenic, androgenic, glucocorticoid, or anabolic effects, although it is an agonist of progesterone receptors (EC₅₀ = 12.3 nM) and an antagonist of androgen, mineralocorticoid, and glucocorticoid receptors (IC₅₀s = 28.6, 82.7, and 363 nM, respectively). Dydrogesterone protects against sound stress-induced abortion in mice when administered at a dose of 1.25 mg per animal prior to the stressor on day five of pregnancy. Formulations containing dydrogesterone have been used in hormone replacement therapy, in the treatment of menstrual disorders, and to prevent miscarriage.

• Chemische Eigenschaften

  Light Yellow Solid

• Originator

  Duphaston,Duphar,UK,1961

• Verwenden

  central stimulant, convulsant

• Verwenden

  A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.

• Definition

  ChEBI: Dydrogesterone is a 3-oxo-Delta(4) steroid and a 20-oxo steroid. It has a role as a progestin.

• Application

  Dydrogesterone is a synthetic progestin. Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS.

• Manufacturing Process

  A solution of 7.5 grams of retroprogesterone in 500 ml of freshly distilled tertiary butyl alcohol was refluxed with 12.75 grams of finely powdered chloranil, while stirring, for 5 hours in a nitrogen atmosphere. After cooling, 2 liters of water were added and extraction was performed three times with 200 ml of methylene dichloride. The combined extracts were then diluted with 1 liter of petroleum ether (40-60°C) washed successively with 100 ml of diluted Na2SO4, four times with 75 ml of 1 N NaOH, and then water to neutral reaction.
  By drying this solution on Na2SO4, and evaporating to dryness (last part in vacuo) 3.7 grams of crystalline residue was obtained. This residue was then dissolved in benzene. Filtration in benzene filtered through 35 grams of alumina (according to Brockmann was done and then the alumina was eluted with benzene. Evaporation of the benzene yielded 3.11 grams of crystalline residue. By crystallization with 15 ml of acetone at room temperature (at lower temperatures a by-product crystallized out) 900 mg of crystals, with a melting point of 165°-170°C were obtained. Transfer of the acetone mother liquor into a mixture of ethanol and hexane yielded 1.7 grams of a solid substance with a melting point of 130° to 145°C. This solid was then recrystallized with acetone at room temperature, yielding 600 mg of a solid with a melting point of 166° to 171°C. The two fairly pure fractions (600 mg and 900 mg) yielded, after crystallization with a mixture of acetone and hexane, finally 1.0 gram of 6-dehydroretroprogesterone, melting point 169° to 170°C. From the mother liquors an additional fraction of 0.44 gram with a melting point of 168° to 169°C was obtained.

• Trademarks

  Gynorest (Solvay Pharmaceuticals).

• Therapeutic Function

  Progestin

• Nebenwirkungen

  Depression, feeling dizzy, vomiting, liver problems (jaundice (yellow eyes), weakness, stomach pain, generalized discomfort), allergic skin reactions (rashes, itching, redness), weight gain.

• Synthese

  Dissolving progesterone, and carrying out photochemical reaction to obtain 9 beta, 10 alpha-pregn-4-ene-3, 20-diketone; mixing the 9 beta, 10 alpha-pregn-4-ene-3, 20-dione, an organic solvent and a benzoquinone oxidant, and carrying out dehydrogenation oxidation reaction to obtain dydrogesterone.

Dydrogesterone Upstream-Materialien And Downstream Produkte

Dydrogesteron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(314)Suppliers

152-62-5, Dydrogesterone Verwandte Suche: