Benzaldehyde, 4-hydroxy-3-nitro-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone

Benzaldehyde, 4-hydroxy-3-nitro-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  L82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells[1][2].

• Einzelnachweise

  [1] Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39. DOI:10.1016/j.dnarep.2017.10.002
  [2] Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-77. DOI:10.1158/0008-5472.CAN-07-6636

Benzaldehyde, 4-hydroxy-3-nitro-, 2-(5-chloro-1,6-dihydro-6-oxo-4-pyridazinyl)hydrazone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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