Paraffinoele

Bezeichnung:Paraffinoele

CAS-Nr8012-95-1

Englisch Name:Paraffin, liquid

CBNumberCB5266104

Summenformelunspecified

Molgewicht0

MOL-DateiMol file

Synonyma

Paraffinoele

Paraffinoele physikalisch-chemischer Eigenschaften

Schmelzpunkt	-24 °C (lit.)
Siedepunkt	300 °C (lit.)
Dichte	0.827-0.890 g/mL at 20 °C
Brechungsindex	n20/D 1.467(lit.)
Flammpunkt	>300°C
storage temp.	Store at room temperature.
Löslichkeit	Practically insoluble in ethanol (95%), glycerin, and water; soluble in acetone, benzene, chloroform, carbon disulfide, ether, and petroleum ether. Miscible with volatile oils and fixed oils, with the exception of castor oil.
Aggregatzustand	light oil
Farbe	white
Wichte	0.870 (20/4℃)
Geruch (Odor)	Odorless
Wasserlöslichkeit	Soluble in ether. Sparingly soluble in ethanol. Not miscible or difficult to mix in water.
Merck	14,7023
Expositionsgrenzwerte	ACGIH: TWA 5 mg/m3 OSHA: TWA 5 mg/m3 NIOSH: IDLH 2500 mg/m3; TWA 5 mg/m3; STEL 10 mg/m3
Dielectric constant	2.0（Ambient）
EPA chemische Informationen	Paraffin oils (8012-95-1)

Sicherheit

Kennzeichnung gefährlicher	Xi,N
R-Sätze:	36-51/53
S-Sätze:	26-61
OEB	B
OEL	TWA: 5 mg/m3, STEL: 10 mg/m3
WGK Germany	1
RTECS-Nr.	PY8030000
Selbstentzündungstemperatur	245°C
TSCA	Yes
HS Code	27122090
Giftige Stoffe Daten	8012-95-1(Hazardous Substances Data)
Toxizität	LD50 oral in rat: > 24gm/kg
IDLA	2,500 mg/m3

Gefahreninformationscode (GHS)

Paraffin, liquid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Mineral oil mist is a colorless, oily liquid aero-sol dispersed in air with an odor like burned lubricating oil.The odor threshold is 1.0 ppm. Specific gravity (H2O:1)=0.865 at 60℃; Boiling point = 250- 360*C; Vaporpressure = <0.5 mmHg at 20℃; Flash point= 193℃;Autoignition temperature = 260- 371℃. HazardIdentification (based on NFPA-704 M Rating System):Health 0, Flammability 1, Reactivity 0. Insoluble in water.
Chemische Eigenschaften
Clear colorless oil
Chemische Eigenschaften
Mineral oil is a transparent, colorless, viscous oily liquid, without fluorescence in daylight. It is practically tasteless and odorless when cold, and has a faint odor of petroleum when heated.
Verwenden
Mineral oil is a lubricant and is used as a solvent for inks in the printing industry.
Verwenden
Laxative; pharmaceutic aid (solvent).
Verwenden
Paraffin Oils is a useful organic solvent for isolating the nucleus of the gian amphibian oocyte.
Vorbereitung Methode
Mineral oil is obtained by distillation of petroleum. The lighter hydrocarbons are first removed by distillation and the residue is then redistilled between 330–390°C. The distillate is chilled and the solid fractions are removed by filtration. The filtrate is then further purified and decolorized by high-pressure hydrogenation or sulfuric acid treatment; the purified filtrate is then filtered through adsorbents. The liquid portion obtained is distilled and the portion boiling below 360°C is discarded. A suitable stabilizer may be added to the mineral oil;
Definition
Liquid hydrocarbons from petroleum.
Trademarks
Balneol (Solvay Pharmaceuticals); Neo-Cultol (Fisons); Nujol (Schering-Plough HealthCare).
Allgemeine Beschreibung
Transparent colorless oily liquid. Practically tasteless and odorless, even when warmed.
Air & Water Reaktionen
Flammable. Insoluble in water.
Reaktivität anzeigen
OIL. [MINERAL] may be incompatible with strong oxidizing agents like nitric acid. Charring may occur followed by ignition of unreacted oil and other nearby combustibles. In other settings, mostly unreactive. Not affected by aqueous solutions of acids, alkalis, most oxidizing agents, and most reducing agents. Burns exothermically when heated sufficiently or when ignited in the presence of air, oxygen or strong oxidizing agents.
Hazard
Inhalation of vapor or particulates can causeaspiration pneumonia. Combustible liquid. Upperrespiratory tract irritant. Questionable carcinogen.
Health Hazard
Highly refined mineral oil mist is of low toxicity.
Brandgefahr
PARAFFIN is combustible.
Pharmazeutische Anwendungen
Mineral oil is used primarily as an excipient in topical pharmaceutical formulations, where its emollient properties are exploited as an ingredient in ointment bases. It is additionally used in oil-in-water emulsions,as a solvent, and as a lubricant in capsule and tablet formulations, and to a limited extent as a mold-release agent for cocoa butter suppositories. It has also been used in the preparation of microspheres and as a vaccine adjunct.
Therapeutically, mineral oil has been used as a laxative.It is indigestible and thus has limited absorption. Mineral oil is used in ophthalmic formulations for its lubricant properties. It is also used in cosmetics and some food products.
Sicherheitsprofil
A human teratogen by inhalation that causes testicular tumors in the fetus. Inhalation of vapor or particulates can cause aspiration pneumonia. A skin and eye irritant. Highly purified food grades are of low toxicity. Questionable human carcinogen producing gastrointestinal tumors. Slightly combustible liquid when exposed to heat or flame. To fight fire, use dry chemical, CO2, foam. When heated to decomposition it emits acrid smoke and fumes.
Sicherheit(Safety)
Mineral oil is used as an excipient in a wide variety of pharmaceutical formulations. It is also used in cosmetics and in some food products.
Therapeutically, mineral oil has been used in the treatment of constipation, as it acts as a lubricant and stool softener when taken orally. Daily doses of up to 45mL have been administered orally, while doses of up to 120mL have been used as an enema. However, excessive dosage of mineral oil, either orally or rectally, can result in anal seepage and irritation, and its oral use as a laxative is not considered desirable.
Chronic oral consumption of mineral oil may impair the appetite and interfere with the absorption of fat-soluble vitamins. Prolonged use should be avoided. Mineral oil is absorbed to some extent when emulsified and can lead to granulomatous reactions. Similar reactions also occur upon injection of the oil;injection may also cause vasospasm.
The most serious adverse reaction to mineral oil is lipoid pneumonia caused by aspiration of the oil.Mineral oil can enter the bronchial tree without eliciting the cough reflex.With the reduction in the use of mineral oil in nasal formulations, the incidence of lipoid pneumonia has been greatly reduced. However, lipoid pneumonia has also been associated with the use of mineral oil-containing cosmetics and ophthalmic preparations.It is recommended that products containing mineral oil not be used in very young children, the elderly, or persons with debilitating illnesses.
Given its widespread use in many topical products, mineral oil has been associated with few instances of allergic reactions. The WHO has not specified an acceptable daily intake of mineral oil given the low concentration consumed in foods.
LD₅₀ (mouse, oral): 22 g/kg
mögliche Exposition
Tumorigen,Human Data; Primary Irritant. Mineral oil is used in cosmetics, pharmaceutical bases, food, and fiber production; ascarriers and bases; as a lubricating oil; and as a solvent forinks in the printing industry. Oil mist would be encounteredin quenching of hot metal parts and in metal machiningoperations.
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility
Lager
Mineral oil undergoes oxidation when exposed to heat and light. Oxidation begins with the formation of peroxides, exhibiting an ‘induction period’. Under ordinary conditions, the induction period may take months or years. However, once a trace of peroxide is formed, further oxidation is autocatalytic and proceeds very rapidly. Oxidation results in the formation of aldehydes and organic acids, which impart taste and odor. Stabilizers may be added to retard oxidation; butylated hydroxyanisole, butylated hydroxytoluene, and alpha tocopherol are the most commonly used antioxidants.
Mineral oil may be sterilized by dry heat.
Mineral oil should be stored in an airtight container, protected from light, in a cool, dry place.
läuterung methode
Treat the oil with fuming H2SO4 (care), then wash it with water and dilute aqueous NaOH, then percolate it through activated silica gel. Paraffin Wax. Melt the wax in the presence of NaOH, wash it with water until all of the base had been removed. The paraffin is allowed to solidify after each wash. Finally, 5g of paraffin is melted by heating it on a water-bath, then shaken for 20-30minutes with 100mL of boiling water and and dry the melt under vacuum.
Inkompatibilitäten
Incompatible with strong oxidizing agents.
Filter für giftige stoffe
The initial threshold screening level (ITSL) for mineral oil (CAS# 8012-95-1) is 50 μg/m3 on an 8-hour averaging time.
Regulatory Status
GRAS listed. Accepted in the UK for use in certain food applications. Included in the FDA Inactive Ingredients Database (dental preparations; IV injections; ophthalmic preparations; oral capsules and tablets; otic, topical, transdermal, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Paraffin, liquid Upstream-Materialien And Downstream Produkte

Paraffinoele Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

8012-95-1, Paraffin, liquid Verwandte Suche:

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