5-Ethyl-5-(1-methylbutyl)-2-thiobarbitursure

Bezeichnung:5-Ethyl-5-(1-methylbutyl)-2-thiobarbitursure

CAS-Nr76-75-5

Englisch Name:(+/-)-THIOPENTAL

CBNumberCB5265910

SummenformelC11H18N2O2S

Molgewicht242.34

MOL-Datei76-75-5.mol

Synonyma

5-Ethyl-5-(1-methylbutyl)-2-thiobarbitursure

5-Ethyl-5-(1-methylbutyl)-2-thiobarbitursure physikalisch-chemischer Eigenschaften

Schmelzpunkt	158-160°C
Dichte	1.1789 (rough estimate)
Brechungsindex	1.5440 (estimate)
Flammpunkt	11℃
storage temp.	2-8°C
Löslichkeit	ethanol: complete50mg/mL
pka	7.11±0.40(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	50mg/L(25 ºC)
CAS Datenbank	76-75-5(CAS DataBase Reference)
EPA chemische Informationen	4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (76-75-5)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	22-39/23/24/25-23/24/25-11
S-Sätze:	36/37/39-45-36/37-16-7
RIDADR	UN 1230 3/PG 2
WGK Germany	3
RTECS-Nr.	CQ6300000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2933595960
Giftige Stoffe Daten	76-75-5(Hazardous Substances Data)
Toxizität	cyt-hmn:leu 1500 mg/L TGANAK18(1),13,84

Gefahreninformationscode (GHS)

(+/-)-THIOPENTAL Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Off-White Solid
Originator
Pentothal,Abbott
Verwenden
A thio-derivative of Barbituric acid. Controlled substance (depressant). Anesthetic
Definition
ChEBI: Thiopental is a barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups. It has a role as an anticonvulsant, a sedative, an environmental contaminant, a xenobiotic, a drug allergen and an intravenous anaesthetic. It is functionally related to a 2-thiobarbituric acid. It is a conjugate acid of a thiopental(1-).
Manufacturing Process
130 g of ethyl (1-methylbutyl) malonic ester is added to a concentrated solution of sodium ethylate prepared from 34 g of sodium in absolute alcohol; with stirring, 60 g of finely divided thiourea is added, and, the mixture refluxed for 10 hours. Most or all of the solvent is evaporated and the residual mass is dissolved in cold water. The barbituric acid derivative so formed is precipitated by the addition of dilute hydrochloric acid. It may be 1 purified by solution in dilute ammonium hydroxide solution and precipitated by carbon dioxide, followed by recrystallization from 95% alcohol. The ethyl (1- methylbutyl)thiobarbituric acid so obtained is a white crystalline solid, melting at 158-159°C and readily forming salts with alkalies.
Trademarks
Thiopental is BAN.
Therapeutic Function
Narcotic analgesic, Anesthetic
Sicherheitsprofil
Poison by intraperitoneal, intravenous, and rectal routes. Moderately toxic by ingestion. An experimental teratogen. Human mutation data reported. A short-acting intravenous anesthetic. When heated to decomposition it emits very toxic fumes of NOx and SOx

(+/-)-THIOPENTAL Upstream-Materialien And Downstream Produkte

5-Ethyl-5-(1-methylbutyl)-2-thiobarbitursure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

76-75-5, (+/-)-THIOPENTAL Verwandte Suche:

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