OU749

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P330：Mund ausspülen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

OU749 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  ou749 is a competitive inhibitor of γ-glutamyl transpeptidase (ggt) [1].expression of γ-glutamyl transpeptidase (ggt) in tumors contributes to the resistance to radiation and chemotherapy. ggt is inhibited by glutamine analogues which compete with the substrate for the γ-glutamyl binding site [1].ou749 inhibited human kidney ggt with an intrinsic ki of 17.6 m [1]. in 786-o cells, a human renal tumor cell line, ou749 showed more than 150-fold less toxic than the ggt inhibitor acivicin toward dividing cells. ou749 inhibited ggt isolated from human kidney in a dose-dependent manner [1]. ou749 was 7-fold less potent as inhibitor of ggt isolated from rat kidney and 10-fold less potent inhibiting ggt from mouse kidney [1]. ou749 did not inhibit degradation of glutathione by ggt from rat kidney. inhibition of ggt by ou749 is species-specific [1]. ou749 showed no inhibitory effect on ggt from pig cells. ou749 inhibited human ggt expressed in mouse fibroblasts by a similar extent to the ggt from human cells, indicated that the species specificity was determined by differences in the primary structure of the protein rather than species-specific, post-translational modifications [1].

• Einzelnachweise

  [1] king j b, west m b, cook p f, et al. a novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase[j]. journal of biological chemistry, 2009, 284(14): 9059-9065.

OU749 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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