Chonglou Saponin VII

Chonglou Saponin VII Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

• Verwenden

  Used for content determination/identification/pharmacological experiments, etc.

• Biologische Aktivität

  Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.

• Pharmakologie

  Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.

• in vitro

  Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase.

• in vivo

  Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.

• target

  Akt

  p38

  Bcl-2

  Caspase-9

  Caspase-3

  PARP-1

Chonglou Saponin VII Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(150)Suppliers

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