Chonglou Saponin VII

Bezeichnung:Chonglou Saponin VII

Englisch Name:Chonglou Saponin VII

CBNumberCB52519622

SummenformelC51H82O21

Molgewicht1031.2

Chonglou Saponin VII physikalisch-chemischer Eigenschaften

Sicherheit

HS Code

29329990

Chonglou Saponin VII Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
Verwenden
Used for content determination/identification/pharmacological experiments, etc.
Biologische Aktivität
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.
Pharmakologie
Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.
in vitro

Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase.
in vivo

Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.
target

Akt

p38

Bcl-2

Caspase-9

Caspase-3

PARP-1