4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Struktur

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid

Bezeichnung:4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid

CAS-Nr6501-72-0

Englisch Name:4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid

CBNumberCB52518933

SummenformelC11H11NO3

Molgewicht205.21

MOL-Datei6501-72-0.mol

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid physikalisch-chemischer Eigenschaften

Schmelzpunkt	157-158℃
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Soluble in DMSO (up to 30 mg/ml).
Aggregatzustand	solid
Farbe	White
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-43
S-Sätze:	36/37
HS Code	2934.99.4400

Gefahreninformationscode (GHS)

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
VGX-1027 (6501-72-0) is an immunomodulator that inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function.1?Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality, and type II collagen-induced arthritis in mouse models.1?Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model.2?Modulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model.3?Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling.4
Verwenden
2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid reduces the secretion of IL-1β, TNF-α and IL-10 from purified murine macrophages but not of T cells; and reduces the activation of NF-κB and p38 MAP kinase pathways along with up-regulation of ERK pathways. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid inhibits proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro .
Lager
Store at +4°C
Einzelnachweise
1) Stojanovic?et al.?(2007),?In vitro, ex vivo and in vivo immunopharmacological activities of the isooxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models; Clin. Immunol.,?123?311 2) Stosic-Grujisic?et al.?(2007),?A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice; J. Pharmacol. Exp. Ther.,?320?1038 3) Fagone?et al.?(2014),?VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus; Immunology,?142?594 4) Xu?et al.?(2019),?Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness; Eur. J, Pharmacol.,?842?373

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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