3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester

Bezeichnung:3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester

CAS-Nr35286-58-9

Englisch Name:3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester

CBNumberCB52462159

SummenformelC41H66O13

Molgewicht766.95

MOL-Datei35286-58-9.mol

3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester physikalisch-chemischer Eigenschaften

Schmelzpunkt	198-202 ºC
Siedepunkt	841.9±65.0 °C(Predicted)
Dichte	1.35
storage temp.	-20°C, protect from light
Löslichkeit	Soluble in acetonitrile and methanol;
Aggregatzustand	powder
pka	12.52±0.70(Predicted)
Farbe	White
Wasserlöslichkeit	insoluble in water

3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Burnet.
Verwenden
Used for content determination/identification/pharmacological experiments, etc.
Biologische Aktivität
Ziyuglycoside I, isolated from the roots of S. officinalis, has anti-wrinkle activity and increases collagen type I expression. It can be used as an active ingredient in cosmetics and induces p53-mediated cell cycle arrest and apoptosis (apoptosis), which can be used in the study of triple-negative breast cancer.
Physiological effects
Ziyuglycoside I has the functions of vasoconstriction, hemostasis and antifungal.

in vitro

Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC ₅₀ value of 13.96 μM in MDA-MB-231 cells. Ziyuglycoside I ( 5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM. Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas- 8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression.

Cell Viability Assay

Cell Line:	MDA-MB-231 cells < /td>
Concentration:	5 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 160 μM
Incubation Time:	24 hours
Result:	Showed cytotoxicity on MDA-MB-231 cells.

Cell Cycle Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	5 μM, 10 μM, and 20 μM
Incubation Time:	24 hours
Result:	Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells

Western Blot Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	5 μM, 10 μM, and 20 μM
Incubation Time:	24 hours
Result:	Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.

3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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