(2,5-Dihydroxyphenyl)essigsure

Bezeichnung:(2,5-Dihydroxyphenyl)essigsure

CAS-Nr451-13-8

Englisch Name:HOMOGENTISIC ACID

CBNumberCB5207860

SummenformelC8H8O4

Molgewicht168.15

MOL-Datei451-13-8.mol

Synonyma

(2,5-Dihydroxyphenyl)essigsure

(2,5-Dihydroxyphenyl)essigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	150-152 °C (lit.)
Siedepunkt	257.07°C (rough estimate)
Dichte	1.3037 (rough estimate)
Brechungsindex	1.5090 (estimate)
storage temp.	2-8°C
Löslichkeit	Soluble in methanol.
pka	4.4(at 25℃)
Aggregatzustand	crystalline
Farbe	off-white to tan
Wasserlöslichkeit	very faint turbidity
Merck	14,4737
BRN	2692860
LogP	0.860
CAS Datenbank	451-13-8(CAS DataBase Reference)
EPA chemische Informationen	Benzeneacetic acid, 2,5-dihydroxy- (451-13-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	AH0589000
TSCA	Yes
HS Code	29182900

Gefahreninformationscode (GHS)

HOMOGENTISIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
off-white to tan crystals or crystalline powder
Verwenden
An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics.
Verwenden
Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:
- Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).
- Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).
It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD).
Definition
ChEBI: Homogentisic acid is a dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions. It has a role as a human metabolite and a plant metabolite. It is a dihydroxyphenylacetic acid and a member of hydroquinones. It is functionally related to a phenylacetic acid. It is a conjugate acid of a homogentisate.
Allgemeine Beschreibung
Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.
läuterung methode
Crystallise homogentisic acid from EtOH/CHCl3 or H2O (solubility is 85% at 25o). [Beilstein 10 IV 1506.]

HOMOGENTISIC ACID Upstream-Materialien And Downstream Produkte

(2,5-Dihydroxyphenyl)essigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

451-13-8, HOMOGENTISIC ACID Verwandte Suche:

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