HUMAN M-CSF Struktur

HUMAN M-CSF

Bezeichnung:HUMAN M-CSF

Englisch Name:HUMAN M-CSF

CBNumberCB5201242

Molgewicht0

HUMAN M-CSF physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Aggregatzustand	lyophilized powder
Farbe	white to off-white
Biologische Quelle	rat

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-24/25-26
WGK Germany	3
RTECS-Nr.	GI5500000

Gefahreninformationscode (GHS)

HUMAN M-CSF Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Antineoplastic; anti-infective growth factor that acts on both progenitor and mature cells of the macrophage line.
Verwenden
Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
Allgemeine Beschreibung
M-CSF (macrophage colony-stimulating factor) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The protein works through its receptor CSF1R (colony stimulating factor 1 receptor). The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4kDa homodimeric protein containing two 156 amino acid polypeptide subunits.
Biochem/physiol Actions
M-CSF (macrophage colony-stimulating factor) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. M-CSF also works as a pleiotropic growth factor and plays a crucial role in reproduction and organogenesis. Absence of it can result in reduced growth, neurological and reproductive problems, developmental defects in the mammary gland, bone and pancreas. M-CSF is also involved in the pathogenesis of cancer.

HUMAN M-CSF Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

81627-83-0, HUMAN M-CSF Verwandte Suche:

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