Azosemid

Bezeichnung:Azosemid

Englisch Name:Azosemide

CBNumberCB5200179

SummenformelC12H11ClN6O2S2

Molgewicht370.84

Synonyma

Azosemid

Azosemid physikalisch-chemischer Eigenschaften

Schmelzpunkt	218-221°
Siedepunkt	221°C (rough estimate)
Dichte	1.6843 (rough estimate)
Brechungsindex	1.6100 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Heated)
Aggregatzustand	Solid
pka	3.58±0.10(Predicted)
Farbe	Crystals
CAS Datenbank	27589-33-9(CAS DataBase Reference)

Sicherheit

Toxizität

LD50 orl-rat: 2545 mg/kg IYKEDH 18,666,87

Gefahreninformationscode (GHS)

Beschreibung
Azosemide is a high-ceiling diuretic similiar in structure and profile to furosemide, albeit somewhat less potent and less bioavailable. It is useful in the treatment of congestive heart failure and similar edematous conditions.
Originator
Boehringer Manheim (W. Germany)
Verwenden
Diuretic.
Verwenden
Azosemide is a high-ceiling diuretic agent. It is used in the treatment of edematous states and hypertension.
Definition
ChEBI: A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hyp rtension.
Manufacturing Process
The 4-chloro-5-sulfamoyl-2-thenylaminobenzonitrile used as starting material is obtained by the reaction of 4-chloro-2-fluoro-5-sutfamoyl-benzonitrile with thenylamine in anhydrous tetrahydrofuran.
Then the 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)phenyltetrazole (MP 218° to 221°C, yield 37% of theory) is obtained by the reaction of 4-chloro-5- sulfamoyl-2-thenylaminobenzonitrite (MP 170° to 174°C) with sodium azide and ammonium chloride,
Trademarks
LURET
Therapeutic Function
Diuretic
Sicherheitsprofil
Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion andsubcutaneous routes. An experimental teratogen. Whenheated to decomposition it emits toxic fumes of Cl^-, SOx,and NOx.