3',4',5'-TRIFLUOROACETOPHENONE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P405：Unter Verschluss aufbewahren.

3',4',5'-TRIFLUOROACETOPHENONE Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  colorless to clear liquid

• Verwenden

  3',4',5'-Trifluoroacetophenone is an organic intermediate that can be used to prepare the key mother nucleus (S)-N-[4-(1-aminoethyl)-2,6-difluorophenyl]methanesulfonamide of vanilloid compounds.

• Synthese

  

  108-24-7

  

  138526-69-9

  

  220141-73-1

  The general procedure for the synthesis of 3,4,5-trifluoroacetophenone from ethanoic anhydride and 3,4,5-trifluorobromobenzene was carried out as follows: firstly, iodine (361 mg, 1.42 mmol) was added to a solution of magnesium (3.53 g, 145 mmol) in tetrahydrofuran (100 ml) at room temperature, followed by slow dropwise addition of 3,4,5-trifluorobromobenzene (30.0 g, 142 mmol). The reaction mixture was stirred at the same temperature for 30 minutes. Next, a toluene solution (100 ml) containing copper (I) chloride (704 mg, 7.11 mmol) and acetic anhydride (16.0 g, 156 mmol) was added to the reaction mixture at 0°C. The reaction mixture was continued to be stirred at 0°C for 1 hour. After completion of the reaction, the mixture was poured into 2N aqueous hydrochloric acid solution and extracted with toluene. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The concentrated product was purified by silica gel column chromatography using ethyl acetate/hexane (1/10) as elution solvent to give 3,4,5-trifluoroacetophenone as a final yellow oil (yield 21.0 g, 85% yield).

• Einzelnachweise

  [1] Patent: JP2016/84346, 2016, A. Location in patent: Paragraph 0056
  [2] Patent: JP2016/84328, 2016, A. Location in patent: Paragraph 0191

3',4',5'-TRIFLUOROACETOPHENONE Upstream-Materialien And Downstream Produkte

3',4',5'-TRIFLUOROACETOPHENONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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