Propyphenazon

Bezeichnung:Propyphenazon

CAS-Nr479-92-5

Englisch Name:Propyphenazone

CBNumberCB5193729

SummenformelC14H18N2O

Molgewicht230.31

MOL-Datei479-92-5.mol

Synonyma

Propyphenazon

Propyphenazon physikalisch-chemischer Eigenschaften

Schmelzpunkt	102-105°C
Siedepunkt	372.3°C (rough estimate)
Dichte	1.0371 (rough estimate)
Brechungsindex	1.5500 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
pka	1.46±0.65(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	743.6g/L(25.35 ºC)
Merck	14,7871
BRN	204533
Stabilität	Stable. Incompatible with strong oxidizing agents.
CAS Datenbank	479-92-5(CAS DataBase Reference)
NIST chemische Informationen	Propyphenazone(479-92-5)
EPA chemische Informationen	3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-22
S-Sätze:	26-36/37/39
WGK Germany	3
RTECS-Nr.	CD2800000
HS Code	2933.39.9200

Gefahreninformationscode (GHS)

Propyphenazone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.
Chemische Eigenschaften
solid
Verwenden
Analgesic; antipyretic; anti-inflammatory.
Definition
ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.
Trademarks
539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.
Weltgesundheitsorganisation (WHO)
Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.
Clinical Use
Propyphenazone is a derivative of phenazone and has a similar analgesic and antipyretic action. It is used as a monocompound as well as in multi-ingredient preparations.
Einzelnachweise
Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)

Propyphenazon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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