2-Imidazol-4-ylethylamindihydrochlorid

Bezeichnung:2-Imidazol-4-ylethylamindihydrochlorid

CAS-Nr56-92-8

Englisch Name:Histamine dihydrochloride

CBNumberCB5183827

SummenformelC5H11Cl2N3

Molgewicht184.07

MOL-Datei56-92-8.mol

Synonyma

2-Imidazol-4-ylethylamindihydrochlorid

2-Imidazol-4-ylethylamindihydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	249-252 °C(lit.)
storage temp.	2-8°C
Löslichkeit	H₂O: 0.1 g/mL, clear, colorless
Aggregatzustand	powder
Farbe	white to off-white
Wasserlöslichkeit	SOLUBLE
Merck	14,4719
BRN	3624116
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	PPZMYIBUHIPZOS-UHFFFAOYSA-N
CAS Datenbank	56-92-8(CAS DataBase Reference)
EPA chemische Informationen	1H-Imidazole-4-ethanamine, dihydrochloride (56-92-8)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36/37/38-42/43-42-22
S-Sätze:	22-26-36/37/39-45-37-36/37
RIDADR	3335
WGK Germany	2
RTECS-Nr.	MS1575000
F	1-8-9
TSCA	Yes
HazardClass	IRRITANT
HS Code	29332900

Gefahreninformationscode (GHS)

Histamine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R42:Sensibilisierung durch Einatmen möglich.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37:Geeignete Schutzhandschuhe tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
white powder
Verwenden
Histamine dihydrochloride has been used:
- as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
- to determine its level in fish using HPLC (high performance liquid chromatography)
- to assess the tracheal response to antigens in guinea-pigs
Verwenden
Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter.
Verwenden
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.
Allgemeine Beschreibung
Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biologische Aktivität
Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo .
Biochem/physiol Actions
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor.
Lager
Room temperature (desiccate)
läuterung methode
The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.]

2-Imidazol-4-ylethylamindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

56-92-8, Histamine dihydrochloride Verwandte Suche:

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