Oxycodon

Bezeichnung:Oxycodon

CAS-Nr76-42-6

Englisch Name:OXYCODONE

CBNumberCB5166312

SummenformelC18H21NO4

Molgewicht315.36

MOL-Datei76-42-6.mol

Synonyma

Oxycodon

Oxycodon physikalisch-chemischer Eigenschaften

Schmelzpunkt	218-220°
Siedepunkt	454.92°C (rough estimate)
Dichte	1.2164 (rough estimate)
Brechungsindex	1.5740 (estimate)
Flammpunkt	9℃
storage temp.	2-8°C
Löslichkeit	DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml
Aggregatzustand	A neat solid
pka	8.53(at 25℃)
Farbe	Long rods from EtOH
EPA chemische Informationen	Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5.alpha.)- (76-42-6)

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	11-23/24/25-39/23/24/25
S-Sätze:	7-16-36/37-45
RIDADR	1544
WGK Germany	1
HazardClass	6.1(a)
PackingGroup	II
HS Code	2939110000
Giftige Stoffe Daten	76-42-6(Hazardous Substances Data)
Toxizität	LD50 intraperitoneal in mouse: 320mg/kg

Gefahreninformationscode (GHS)

OXYCODONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Oxycodone (Item No. 15465) is an analytical reference material categorized as an opioid. Oxycodone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Originator
Oxyfast,Purdue Pharma, L.P.
Verwenden
Analgesic (narcotic).
Definition
oxycodone: An opioid, C₁₈H₂₁N₂,similar in structure to codeine butwith a –OH group in codeine replacedby a carbonyl group. It is ananalgesic often used for the treatmentof chronic pain. It is also usedillegally and is a controlled substancein most countries.
Trademarks
Oxycontin (Purdue); Roxicodone (Roxane); Roxicodone (Xanodyne).
Therapeutic Function
Narcotic analgesic
Biologische Funktion
Oxycodone is nearly 10 times as strong as codeine, with absorption equal to that of orally administered morphine. Neither hydromorphone nor oxycodone is approved for use in children, and hydromorphone is contraindicated in obstetrical analgesia and in asthmatics.
Allgemeine Beschreibung
Oxycodone is synthesized from the natural opium alkaloidthebaine. Oxycodone is the 14 beta-hydroxyl version of hydrocodone.This additional functional group gives oxycodonegreater potency (1.5 times orally) than hydrocodone presumablyby increasing receptor affinity. The oral bioavailabilityof oxycodone is 65% to 87%. The metabolism of oxycodonefollows the similar pattern of opioid metabolism withN-demethylation, O-demethylation, and their glucuronides allidentified. Per the manufacturer, the analgesic effect of oxycodonecorrelates well with oxycodone plasma concentrations,not the minimal amount of oxymorphone formed, thusoxycodone is not assumed to be a prodrug. There are no largescalestudies of oxycodone used for analgesia in CYP2D6poor metabolizers that can confirm this.
Oxycodone is marketed in combination with acetaminophen(Percocet), aspirin (Percodan), and ibuprofen(Combunox). It has been available for over 50 years as animmediate-release tablet, and in 1995 an extended-releasetablet was approved by the FDA (OxyContin). OxyContin ismanufactured in eight strengths from 10 to 160 mg, and thehigh-dose preparations quickly became attractive to drugabusers. The extended-release tablets are crushed and theninjected or snorted to give an immediate high. The DrugAbuse Warning Network (DAWN) is a public health surveillancesystem that monitors drug-related emergency roomvisits and drug-related deaths. In 1995, they estimated that598,542 emergency room visits involved the nonmedical useof a pharmaceutical (e.g., antidepressant, anxiolytic, stimulant).Of these ER visits, 160,363 visits were attributed toopiates with an estimated 42,810 involving oxycodone or anoxycodone combination. Methadone and hydrocodone/combinationswere estimated to be similar to oxycodone.
Pharmakologie
Oxycodone is a potent semisynthetic opioid that has been in use for many years. In addition to actions at the MOP receptor, it may also have analgesic effects mediated via the KOP receptor, resulting in incomplete crosstolerance with morphine. It has a good oral bioavailability, and its plasma concentrations are more predictable than those of morphine after oral administration. It is available in both long- and short-acting oral preparations and, more recently, in a parenteral formulation. Oral oxycodone is roughly 1.5 times more potent than oral morphine.
Sicherheitsprofil
Poison by intraperitoneal route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.

OXYCODONE Upstream-Materialien And Downstream Produkte

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