DNOC

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H317：Kann allergische Hautreaktionen verursachen.

  H318：Verursacht schwere Augenschäden.

  H341：Kann vermutlich genetische Defekte verursachen.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P201：Vor Gebrauch besondere Anweisungen einholen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-Methyl-4,6-dinitrophenol Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  GERUCHLOSE GELBE KRISTALLE.

• PHYSIKALISCHE GEFAHREN

  Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich.

• CHEMISCHE GEFAHREN

  Zersetzung beim Verbrennen unter Bildung giftiger Rauche mit Stickstoffoxiden. Reagiert sehr heftig mit starken Oxidationsmitteln.

• ARBEITSPLATZGRENZWERTE

  TLV: 0.2 mg/m?(als TWA); Hautresorption; (ACGIH 2005).
  MAK: IIb (nicht festgelegt, aber Informationen vorhanden) Hautresorption; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C tritt eine gesundheitsschädliche Kontamination der Luft nicht oder nur sehr langsam ein; viel schneller jedoch beim Versprühen oder Dispergieren.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz verätzt die Augen und reizt die Haut. Gelbfärbung der Haut. Möglich sind Auswirkungen auf den Stoffumsatz. Exposition gegenüber hohen Konzentrationen kann zum Tod führen.

• LECKAGE

  Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R38:Reizt die Haut.
  R41:Gefahr ernster Augenschäden.
  R43:Sensibilisierung durch Hautkontakt möglich.
  R44:Explosionsgefahr bei Erhitzen unter Einschluss.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R68:Irreversibler Schaden möglich.
  R40:Verdacht auf krebserzeugende Wirkung.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.
  R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

• S-Sätze Betriebsanweisung:

  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S7:Behälter dicht geschlossen halten.

• Beschreibung

  DNOC exists in 9 isomeric forms of which4,6-dinitro-o-cresol is the most important commercially andthe most heavily regulated. It is a noncombustible, yellowcrystalline solid. Molecular weight= 198.15; Boilingpoint= 312℃; Freezing/Melting point = 88℃; Vaporpressure = 5 3 1025 mmHg. Hazard Identification (based onNFPA-704 M Rating System): Health 3, Flammability 0,Reactivity 0. Practically insoluble in water;solubility 5 0.01%.

• Chemische Eigenschaften

  yellow to yellow-green crystals or cryst. powder

• Verwenden

  2-Methyl-4,6-dinitrophenol can be used as dormant ovicidal spray for fruit trees (highly phytotoxic and cannot be used successfully on actively growing plants); herbicide; insecticide.

• Verwenden

  DNOC is a dinitrophenolic compound which exhibits insecticidal, acaricidal and herbicidal activities. It is a non-selective insecticide and controls aphids, Lepidoptera larva and scale insects on pome fruits and stone fruit trees.

• Verwenden

  4,6-Dinitro-o-cresol is used as a selective herbicide as well as an insecticide.

• Vorbereitung Methode

  o-Cresol is sulfonated in excess 75 % sulfuric acid to give the disulfonic acid. The sulfonation mass is diluted with water, and 2 equivalents of nitric acid are added at 70 ℃ to form the dinitro derivative. The product is separated while molten and washed with hot water.

• Definition

  ChEBI: A hydroxytoluene that is o-cresol carrying nitro substituents at positions 4 and 6.

• Allgemeine Beschreibung

  A yellow solid. Emits toxic oxides of nitrogen fumes when heated to decomposition. Toxic by skin absorption, inhalation or ingestion. Soluble in alcohol, acetone, ether and solutions of sodium or potassium hydroxides.

• Air & Water Reaktionen

  Slightly soluble in water.

• Health Hazard

  Extremely toxic material; probable oral lethal dose is 5-50 mg/kg in humans or between 7 drops and 1 teaspoonful for a 70 kg (150 lb.) person.

• Health Hazard

  4,6-Dinitro-o-cresol exhibits cumulative toxicity in humans; the symptoms of poisoning are manifested when the blood levels of this compound exceeds 15–20 μg/g (ACGIH 1986). Thus chronic exposure to this compound can cause serious health hazard. The signs of toxicity in humans are headache, fever, profuse sweating, rapid pulse and respiration, cough, shortness of breath, and coma. Other symptoms noted are a decrease in hemoglobin, an increase in blood sugar, a loss of muscle tone, dyspnea, kidney and liver injury, and edema of the lung and brain.
  LD50 value, oral (mice): 47 mg/kg
  LD50 value, skin (rats): 200 mg/kg.

• Brandgefahr

  Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

• Landwirtschaftliche Anwendung

  Herbicide, Fungicide, Pesticide: DNOC is widely used in agriculture as a herbicide and pesticide; it is also used in the dyestuff industry. Although 4,6-dinitro-o-cresol (DNOC) is no longer registered for use in the United States, it was used as a blossom-thinning agent on fruit trees and as a fungicide, insecticide, and miticides on fruit trees during the dormant season. It is used in mushroom houses to control foreign fungi; to kill locusts and other insects; and as a pre-harvest desiccant of potatoes and leguminous seed crops. DNOC is used as free radical polymerization inhibitor and agricultural chemical intermediate; widely used in agriculture as a herbicide and pesticide; Hence, individuals formulating or spraying the compound incur the highest risk of exposure to the compound. Not approved for use in EU countries. DNOC’s registration in the U.S. as a pesticide was canceled in 1991. Currently, there are 39 global suppliers.

• Handelsname

  ANTINONIN®; ANTINONNIN®; ARBOROL®; DEGRASSAN®; DEKRYSIL®; DETAL®; DILLEX®; DINOC®; DINURANIA®; DITROSOL®; DNOC®[C]; EFFUSAN®; EFFUSAN 3436®; ELGETOL®; ELGETOL 30®; ELIPOL®; EXTRAR®; FLAVIN-SANDOZ®; HEDOLIT®; HEDOLITE®; K III®; K IV®; KREOZAN®; KREZOTOL 50®; LIPAN®; NEUDORFF DN 50®; NITROFAN®; PROKARBOL®; RAFEX®; RAFEX 35®; RAPHATOX®; SANDOLIN®; SANDOLIN A®; SELINON®; SINOX®; WINTERWASH®

• Sicherheitsprofil

  Human poison by unspecified route. Experimental poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and inhalation: somnolence, headache, abnormal brain recordings from specific areas of the central nervous system, cardlac and gastrointestinal changes. Mutation data reported. An e~7e and skin irritant. Less toxic than the para form, but is still highly toxic. A pesticide. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and other dinitrocresol entries.

• mögliche Exposition

  AgriculturalChemical; Mutagen; Reproductive Effector; Human Data;Primary Irritant. DNOC is used as free radical polymerization inhibitor and agricultural chemical intermediate; widelyused in agriculture as an herbicide and pesticide; it is alsoused in the dyestuff industry. Although 4,6-dinitro-o-cresol(DNOC) is no longer manufactured in the United States, alimited quantity is imported and used as a blossom-thinningagent on fruit trees and as a fungicide, insecticide, and miticide, on fruit trees during the dormant season. Hence, individuals formulating or spraying the compound incur thehighest risk of exposure to the compound.

• Carcinogenicity

  In one chronic feeding study in rats DNOC did not cause an increased incidence of any type of tumor. DNOC was clastogenic, increasing the frequency of chromosomal aberrations both in vivo and in vitro. Conflicting results for mutagenicity have been obtained in bacterial assays.
  The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for dinitro-o-cresol is 0.2mg/m3 with a notation for skin absorption.

• Environmental Fate

  Soil/Plant. In plants and soils, the nitro groups reduced to amino groups (Hartley and Kidd, 1987). When 4,6-dinitro-o-cresol was statically incubated in the dark at 25°C with yeast extract and settled domestic wastewater inoculum, no signi?cant biodegradation and necessary acclimation for optimum biooxidation within the 4-week incubation period was observed (Tabak et al., 1981).
  Chemical/Physical. 4,6-Dichloro-o-cresol will react with amines and alkali metals forming water-soluble salts which are indicative of phenols (Morrison and Boyd, 1971).

• Stoffwechselwegen

  DNOC is metabolised in soils, plants and animals via common metabolic pathways. The primary reaction is the reduction of the nitro groups to the corresponding amino-analogues. Acetylation and deamination via hydroxylation/elimination follow. N- and O-Conjugation as glucosides and glucuronides occurred in plants and animals. The metabolic pathways of DNOC are presented in Scheme 1.

• läuterung methode

  The cresol crystallises from aqueous EtOH. [Beilstein 6 H 369, 6 III 1276.]

• Degradation

  DNOC (1) is stable to hydrolytic and photolytic degradation at acidic pH and is readily degraded under alkaline conditions (Molnar, 1935).

• Inkompatibilitäten

  Dust can form an explosive mixture withair. Keep away from strong oxidizers, strong bases. Protectfrom heat and shock

2-Methyl-4,6-dinitrophenol Upstream-Materialien And Downstream Produkte

534-52-1, 2-Methyl-4,6-dinitrophenol Verwandte Suche: