5-Ethyl-5-phenyl-barbitursäure,Natrium-Salz

Bezeichnung:5-Ethyl-5-phenyl-barbitursäure,Natrium-Salz

CAS-Nr57-30-7

Englisch Name:Phenobarbital sodium

CBNumberCB5147742

SummenformelC12H12N2O3.Na

Molgewicht254.22

MOL-Datei57-30-7.mol

Synonyma

Phenobarbitalnatrium

5-Ethyl-5-phenyl-barbitursäure,Natrium-Salz

5-Ethyl-5-phenyl-barbitursäure,Natrium-Salz physikalisch-chemischer Eigenschaften

Schmelzpunkt	175°C
Löslichkeit	H₂O: 1 g/mL
Aggregatzustand	Solid
Farbe	White to Off-White
PH	pH (100g/l, 25℃) : 9.0～11.0
Wasserlöslichkeit	>=10 g/100 mL at 20 ºC
Merck	13,7319
BRN	3802044
Stabilität	Hygroscopic
CAS Datenbank	57-30-7(CAS DataBase Reference)
EPA chemische Informationen	Phenobarbital sodium (57-30-7)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-40-43
S-Sätze:	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	-
RTECS-Nr.	CQ7000000
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 orally in rats: 660 mg/kg (Schaffarzick, Brown)

Gefahreninformationscode (GHS)

Phenobarbital sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II).
Verwenden
Anticonvulsant; sedative-hypnotic.
Verwenden
Phenobarbital sodium salt has been used:
- to anesthetize mice for inducing ischemia-reperfusion injury
- as a positive control for the activation of constitutive androstane receptor (CAR)
- in bioluminescent yeast bioreporters (BLYAS) assay
Definition
ChEBI: A barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups).
Trademarks
Luminal Sodium (Sterling Winthrop).
Allgemeine Beschreibung
Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic.
Air & Water Reaktionen
Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days.
Reaktivität anzeigen
Phenobarbital sodium can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances .
Brandgefahr
Flash point data for Phenobarbital sodium are not available; however, Phenobarbital sodium is probably combustible.
Biochem/physiol Actions
Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA?receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intravenous, intraperitoneal, intraduodenal, and subcutaneous routes. Human systemic effects by ingestion: nausea or vomiting and coma. Experimental reproductive effects. Mutation data reported. Used to treat epilepsy, as a hypnotic and sedative. When heated to decomposition it emits toxic fumes of NOx and NazO. See also BARBITURATES

Phenobarbital sodium Upstream-Materialien And Downstream Produkte

5-Ethyl-5-phenyl-barbitursäure,Natrium-Salz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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