PHORBOL 12,13-DIBUTYRATE Struktur

PHORBOL 12,13-DIBUTYRATE

Bezeichnung:PHORBOL 12,13-DIBUTYRATE

CAS-Nr37558-16-0

Englisch Name:PHORBOL 12,13-DIBUTYRATE

CBNumberCB5117703

SummenformelC28H40O8

Molgewicht504.61

MOL-Datei37558-16-0.mol

PHORBOL 12,13-DIBUTYRATE physikalisch-chemischer Eigenschaften

Siedepunkt	513.95°C (rough estimate)
Dichte	1.1270 (rough estimate)
Brechungsindex	1.4480 (estimate)
storage temp.	-20°C
Löslichkeit	H₂O: 30 μM
pka	11.15±0.70(Predicted)
Aggregatzustand	powder
Farbe	clear, light yellow, film
BRN	6551234
CAS Datenbank	37558-16-0(CAS DataBase Reference)
EPA chemische Informationen	Phorbol 12,13-dibutyrate (37558-16-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	2928
WGK Germany	3
RTECS-Nr.	EK7767000
F	8-10
HazardClass	6.1(a)
PackingGroup	II
HS Code	2915601990

Gefahreninformationscode (GHS)

PHORBOL 12,13-DIBUTYRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.
Definition
ChEBI: Phorbol 12,13-dibutanoate is a phorbol ester, a butyrate ester and a tertiary alpha-hydroxy ketone.
Allgemeine Beschreibung
White solid.
Reaktivität anzeigen
PHORBOL 12,13-DIBUTYRATE may be sensitive to prolonged exposure to air, light and ambient temperatures. PHORBOL 12,13-DIBUTYRATE may also be subject to autooxidation.
Brandgefahr
The flash point of PHORBOL 12,13-DIBUTYRATE has not been determined, but PHORBOL 12,13-DIBUTYRATE is probably combustible.
Biologische Aktivität
phorbol 12,13-dibutyrate, a phorbol ester, is an activator of pkc, including the conventional calcium-dependent subtypes (α and γ), the nonconventional calcium-independent isoforms (δ, ε, η), as well as the atypical calcium-independent and dag or phorbol ester-unresponsive subtype (ζ). pkc plays an important role in the regulation of a variety of cellular processes such as exocytosis, gene expression, cell proliferation and differentiation, as well as tumor promotion, thereby representing the major target for tumor-promoting phorbol esters and chemically unrelated tumor promoters. phorbol esters are able to replace the endogenous activator dag in the stimulation of pkc, and participate in the multistage process of tumor formation and progression.1. geiges d, meyer t, marte b, et al. activation of protein kinase c subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. biochemical pharmacology, 1997, 53(6): 865-875.2. middleton jp, khan wa, collinsworth g, et al. heterogeneity of protein kinase c-mediated rapid regulation of na/k-atpase in kidney epithelial cells. journal of biological chemistry, 1993, 268(21): 15958-15964.3. scribner jd, boutwell rk. inflammation and tumor promotion: selective protein induction in mouse skin by tumor promoters. european journal of cancer, 1972, 8(6): 617-621.
Biochem/physiol Actions
Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.
Lager
Store at -20°C

PHORBOL 12,13-DIBUTYRATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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