Hepronicate

Hepronicate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Megrin,Yoshitomi,Japan,1972

• Definition

  ChEBI: Hepronicate is an organic molecular entity.

• Manufacturing Process

  In 50 ml of pyridine were dissolved 50 grams of nicotinic acid and 50 grams of p-toluene-sulfonyl chloride. While stirring, the mixture gradually became hot and colorless, and finally solidified. To the mixture was added dropwise a solution of 19 grams of 2-hexyl-2-(hydroxymethyl)-1,3-propanediol in 400 ml of pyridine at a temperature below 80°C. The mixture was heated at 115° to 125°C on an oil bath for 1 hour. After cooling, the mixture was poured into 300 ml of ice water, and extracted with toluene. The toluene layer was washed in sequence with water, aqueous sodium carbonate and water, dried over potassium carbonate, and then the toluene was distilled off. The oily residue was crystallized from ethanol to give 30 grams of 2-hexyl-2-(hydroxymethyl)- 1,3-propanediol trinicotinate, melting at 94° to 96°C. The yield was 59.5%.

• Therapeutic Function

  Vasodilator

Hepronicate Upstream-Materialien And Downstream Produkte

Hepronicate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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